Document Detail

Antifeedant activity of some polygodial derivatives.
MedLine Citation:
PMID:  18533465     Owner:  NLM     Status:  MEDLINE    
Polygodial (1) and its derivatives acetal 2 (propylene) and 3 (ethylene) were prepared and their antifeedant activity and toxic effects evaluated on several insect species with different feeding ecologies (Spodoptera littoralis, Leptinotarsa decemlineata, Myzus persicae and Rhopalosiphum padi) along with that of polygonone (4). We also tested their selective cytotoxic effects on insect-derived (Spodoptera frugiperda ovarian Sf9 cells) and mammalian Chinese hamster ovary (CHO) cells. The antifeedant activity of these compounds was consistent with the proposed mode of action for antifeedant drimanes, i. e. adduct formation with amino groups for M. persicae and R. padi (dialdehyde > ketoaldehyde > aldehydeacetal). This was not the case for L. decemlineata, and the cytotoxic effects on insect-derived Sf9 and mammalian CHO cells (aldehydeacetal > dialdehyde > ketoaldehyde).
Luis Moreno-Osorio; Manuel Cortés; Verónica Armstrong; María Bailén; Azucena González-Coloma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Zeitschrift für Naturforschung. C, Journal of biosciences     Volume:  63     ISSN:  0939-5075     ISO Abbreviation:  Z. Naturforsch., C, J. Biosci.     Publication Date:    2008 Mar-Apr
Date Detail:
Created Date:  2008-06-06     Completed Date:  2008-08-29     Revised Date:  2009-11-04    
Medline Journal Info:
Nlm Unique ID:  8912155     Medline TA:  Z Naturforsch C     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  215-20     Citation Subset:  IM    
Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad del Bío-Bío, Casilla 447, Chillán, Chile.
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MeSH Terms
Animal Feed
Appetite Depressants / chemistry,  pharmacology
Insects / drug effects,  growth & development*
Larva / drug effects*
Models, Molecular
Molecular Conformation
Plants / parasitology
Sesquiterpenes / chemistry,  pharmacology*
Reg. No./Substance:
0/Appetite Depressants; 0/Sesquiterpenes; 6754-20-7/polygodial

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