| Antiepileptics and the development of congenital anomalies. | |
| | |
MedLine Citation:
|
PMID: 1574169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We are conducting a prospective cohort study of epilepsy and pregnancy to determine the nature and extent of adverse pregnancy outcomes in infants of mothers with epilepsy (IME). Women with epilepsy were enrolled no later than the first trimester and were matched with controls; their infants were examined at 8 weeks by pediatricians blinded to maternal status. A number of variables were compared between case and control infants: birth weight, length, gestational age, head circumference, Apgar scores, feeding difficulties, neonatal irritability, and presence of major malformations and minor anomalies. The number of minor anomalies per infant was greater for IME than for controls (mean, 5.05 and 3.65, p less than 0.0001 per infant, respectively). Prominent occiput was the only anomaly seen significantly more often in IME than in controls (p less than 0.05). |
| | |
Authors:
|
M S Yerby; A Leavitt; D M Erickson; K B McCormick; R B Loewenson; C J Sells; T J Benedetti |
Related Documents
:
|
8515119 - Diagnosis of congenital syphilis by combining treponema pallidum-specific igm detection... 8885539 - Major anomalies in consecutive births in south of beirut. a preliminary report about in... 2817779 - "pure" partial trisomy 3p due to the malsegregation of a balanced maternal translocatio... 20956899 - Congenital muscular torticollis: experience of 14 cases. 15390319 - A family-based association study of congenital left-sided heart malformations and 5,10 ... 19033859 - Proboscis lateralis. 23220549 - Nutritional rickets around the world. 3588059 - Improved accuracy of the occlusion technique for assessing total respiratory compliance... 15502549 - Can neurobehavioral examination predict the presence of cerebral injury in the very low... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Neurology Volume: 42 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1992 Apr |
Date Detail:
|
Created Date: 1992-05-29 Completed Date: 1992-05-29 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 132-40 Citation Subset: AIM; IM |
Affiliation:
|
Oregon Comprehensive Epilepsy Program, Portland 97210. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abnormalities, Drug-Induced* Anticonvulsants / adverse effects*, therapeutic use Apgar Score Birth Weight Carbamazepine / adverse effects, therapeutic use Epilepsy / complications, drug therapy* Female Fetus / drug effects Gestational Age Head / anatomy & histology Humans Hydantoins / adverse effects, therapeutic use Infant Infant, Newborn Phenobarbital / adverse effects, therapeutic use Pregnancy Pregnancy Complications Primidone / adverse effects, therapeutic use Syndrome Valproic Acid / adverse effects, therapeutic use |
| Grant Support | |
ID/Acronym/Agency:
|
MCJ-530553-02-0//PHS HHS; NS-17-1111/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Anticonvulsants; 0/Hydantoins; 125-33-7/Primidone; 298-46-4/Carbamazepine; 50-06-6/Phenobarbital; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Minor anomalies in children of mothers with epilepsy.
Next Document: Epilepsy in pregnancy: developmental outcome of offspring at 12 months.