Document Detail

Antiepileptics and the development of congenital anomalies.
MedLine Citation:
PMID:  1574169     Owner:  NLM     Status:  MEDLINE    
We are conducting a prospective cohort study of epilepsy and pregnancy to determine the nature and extent of adverse pregnancy outcomes in infants of mothers with epilepsy (IME). Women with epilepsy were enrolled no later than the first trimester and were matched with controls; their infants were examined at 8 weeks by pediatricians blinded to maternal status. A number of variables were compared between case and control infants: birth weight, length, gestational age, head circumference, Apgar scores, feeding difficulties, neonatal irritability, and presence of major malformations and minor anomalies. The number of minor anomalies per infant was greater for IME than for controls (mean, 5.05 and 3.65, p less than 0.0001 per infant, respectively). Prominent occiput was the only anomaly seen significantly more often in IME than in controls (p less than 0.05).
M S Yerby; A Leavitt; D M Erickson; K B McCormick; R B Loewenson; C J Sells; T J Benedetti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  42     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-05-29     Completed Date:  1992-05-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  132-40     Citation Subset:  AIM; IM    
Oregon Comprehensive Epilepsy Program, Portland 97210.
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MeSH Terms
Abnormalities, Drug-Induced*
Anticonvulsants / adverse effects*,  therapeutic use
Apgar Score
Birth Weight
Carbamazepine / adverse effects,  therapeutic use
Epilepsy / complications,  drug therapy*
Fetus / drug effects
Gestational Age
Head / anatomy & histology
Hydantoins / adverse effects,  therapeutic use
Infant, Newborn
Phenobarbital / adverse effects,  therapeutic use
Pregnancy Complications
Primidone / adverse effects,  therapeutic use
Valproic Acid / adverse effects,  therapeutic use
Grant Support
MCJ-530553-02-0//PHS HHS; NS-17-1111/NS/NINDS NIH HHS
Reg. No./Substance:
0/Anticonvulsants; 0/Hydantoins; 125-33-7/Primidone; 298-46-4/Carbamazepine; 50-06-6/Phenobarbital; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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