| Antiepileptic treatment in pregnant women: morphological and behavioural effects. | |
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MedLine Citation:
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PMID: 21882118 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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It is well established that children exposed to antiepileptic drugs (AEDs) in utero have an increased risk of adverse pregnancy outcomes including foetal growth retardation, major congenital malformations and impaired postnatal cognitive development. However, due to the significant maternal and foetal risks associated with uncontrolled epileptic seizures, AED treatment is generally maintained during pregnancy in the majority of women with active epilepsy. The prevalence of major malformations in children exposed to AEDs has ranged from 4 to 10%, 2-4 times higher than in the general population. More recent studies suggest a smaller increase in malformation rates. Malformation rates have consistently been higher in association with exposure to valproate than with carbamazepine and lamotrigine. Some prospective cohort studies also indicate reduced cognitive outcome in children exposed to valproate compared to carbamazepine and possibly lamotrigine. Information on pregnancy outcomes with newer generation AEDs other than lamotrigine are still insufficient. |
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Authors:
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Torbjörn Tomson; Dina Battino |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Handbook of experimental pharmacology Volume: - ISSN: 0171-2004 ISO Abbreviation: Handb Exp Pharmacol Publication Date: 2011 |
Date Detail:
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Created Date: 2011-09-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902231 Medline TA: Handb Exp Pharmacol Country: Germany |
Other Details:
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Languages: eng Pagination: 295-315 Citation Subset: IM |
Affiliation:
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Department of Clinical Neuroscience, Karolinska Institutet, S-171 76, Stockholm, Sweden, torbjorn.tomson@karolinska.se. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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