| Antiepileptic drugs modify power of high EEG frequencies and their neural generators. | |
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MedLine Citation:
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PMID: 20402743 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: The clinical and molecular effects of antiepileptic drugs (AEDs) have been extensively investigated. Much less is known about their effects on human electrophysiology. METHODS: Topographic analysis in the frequency domain has been used to analyze 104 electroencephalogram (EEG) epochs of 52 patients presenting with first-ever generalized seizure, with normal MRI and EEG. Patients were treated with valproate, arbamazepine, or lamotrigine in monotherapy (each group n = 13). Thirteen patients without medication served as a control group. RESULTS: Carbamazepine and lamotrigine, both sodium-channel modulators, altered brain topography in the gamma range in the same frequency bands (50-60 Hz). Valproate, which has multiple actions on sodium and calcium channels as well as GABA turnover, modified brain topography in the low gamma range (30-40 Hz). No such changes were found in the control group. For all AEDs, the neural generators were shifted more anteriorly in medial temporal through to inferior frontal regions. CONCLUSION: Decreased gamma-power and anterior shift of neural generators after AED introduction reflect AED influence on human electrophysiology. |
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Authors:
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S Arzy; G Allali; D Brunet; C M Michel; P W Kaplan; M Seeck |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of neurology : the official journal of the European Federation of Neurological Societies Volume: 17 ISSN: 1468-1331 ISO Abbreviation: Eur. J. Neurol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506311 Medline TA: Eur J Neurol Country: England |
Other Details:
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Languages: eng Pagination: 1308-12 Citation Subset: IM |
Affiliation:
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Department of Neurology, University Hospital, Geneva, Switzerland. shahar.arzy@hcuge.ch |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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