Document Detail


Antiendothelial cell antibodies: useful markers of systemic sclerosis.
MedLine Citation:
PMID:  9217568     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Systemic sclerosis (SS) encompasses a wide spectrum of clinical presentations. Antiendothelial cell antibodies (AECA) in patients with primary Raynaud's phenomenon (PRP), limited SS (lSSc), or diffuse SS (dSSc) may help to determine the long-term prognosis of the disease. METHODS: Twenty-seven normal controls, 13 patients with PRP, 36 with lSSc, and 31 with dSSc were included in the study. Sera were examined for the presence of AECA, using a cellular enzyme-linked immunosorbent assay (ELISA). Angiotensin-converting enzyme (ACE) activity, plasma von Willebrand factor antigen (vWfAg), and thrombomodulin (Tm) concentrations were also evaluated. The medical records of 50 of the lSSc and dSSc patients were reviewed and the organ system involvement noted. RESULTS: Antiendothelial cell antibodies were present in 3 patients with PRP, 16 patients with lSSc, and 26 patients with dSSc. These autoantibodies were mainly of the IgG isotype. There was no difference in ACE activity between patients and controls. In contrast, vWfAg and Tm concentrations were higher in patients with PRP relative to controls, and higher in patients with lSSc compared with those with PRP. The presence of AECA was associated with digital scars and ulcers (P < 0.004 and P < 0.003, respectively), severe RP (P < 0.01), grade 3 tortuosity of vessels (P < 0.0004), and lung involvement (P < 0.02). CONCLUSION: The significant trend for AECA to increase with disease severity across the three groups of patients studies suggests that the AECA test can identify subsets of SSc with differing prognoses.
Authors:
K V Salojin; M Le Tonquèze; A Saraux; E L Nassonov; M Dueymes; J C Piette; P Y Youinou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of medicine     Volume:  102     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-07-29     Completed Date:  1997-07-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  178-85     Citation Subset:  AIM; IM    
Affiliation:
Laboratory of Immunology, France.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Autoantibodies / analysis*
Biological Markers / analysis*
Endothelium, Vascular / immunology*
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Middle Aged
Peptidyl-Dipeptidase A / blood
Raynaud Disease / blood,  diagnosis,  immunology
Scleroderma, Localized / blood,  diagnosis,  immunology
Scleroderma, Systemic / blood,  diagnosis*,  immunology
Thrombomodulin / blood
von Willebrand Factor / analysis
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Biological Markers; 0/Thrombomodulin; 0/von Willebrand Factor; EC 3.4.15.1/Peptidyl-Dipeptidase A

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