Document Detail


Antiendothelial cell antibodies in scleroderma correlate with severe digital ischemia and pulmonary arterial hypertension.
MedLine Citation:
PMID:  9517764     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the prevalence of IgG antiendothelial cell antibodies (AECA) in patients with scleroderma (systemic sclerosis, SSc) and to correlate it with clinical spectrum and autoantibody profile. METHODS: Seventy-six patients with SSc and 50 matched healthy controls were studied. Immunological variables were antinuclear antibody (ANA), rheumatoid factor (RF), and Scl-70. IgG-AECA was measured by cellular ELISA. RESULTS: The prevalence of IgG-AECA was 27.6% in patients with SSc compared to 6% in controls (p < 0.01). Forty percent of patients with diffuse disease had this antibody, versus 13.5% of those with limited cutaneous involvement (p < 0.05). Patients with AECA had significantly higher incidence of digital infarcts and gangrene (p < 0.01) and pulmonary arterial hypertension (p < 0.001) than those without. In the AECA positive group, mean IgG-AECA levels (measured by absorbance values) were significantly higher in patients with digital infarcts (0.91+/-0.31 vs 0.60+/-0.05; p < 0.01) and pulmonary arterial hypertension (1.14+/-0.37 vs 0.68+/-0.13; p < 0.001) compared to those without these features. CONCLUSION: IgG-AECA appears to be an important marker for disease severity in scleroderma.
Authors:
V S Negi; N K Tripathy; R Misra; S Nityanand
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  25     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-05-06     Completed Date:  1998-05-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  462-6     Citation Subset:  IM    
Affiliation:
Department of Clinical Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Autoantibodies / blood*
Biological Markers / blood
Endothelium, Vascular / immunology*
Female
Humans
Hypertension, Pulmonary / blood,  complications,  immunology*
Immunoglobulin G / blood*
Ischemia / blood,  complications,  immunology*
Male
Middle Aged
Pulmonary Artery / immunology
Scleroderma, Systemic / blood,  complications,  immunology*
Statistics as Topic
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Biological Markers; 0/Immunoglobulin G; 0/anti-endothelial cell antibody

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