| Antidystonic efficacy of gamma-aminobutyric acid uptake inhibitors in the dtsz mutant. | |
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MedLine Citation:
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PMID: 16183056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the dtsz mutant hamster, a model of paroxysmal dyskinesia in which dystonic episodes occur in response to stress, previous studies suggested that retarded development of gamma-aminobutyric acid (GABA)ergic inhibition plays a critical role in the pathogenesis. In the present study, we therefore examined the effects of selective GABA uptake inhibitors on severity of dystonia in dtsz hamsters. R(-)N-(4,4-di(3-methylthien-2-yl)-but-3-enyl) nipecotic acid hydrochloride (tiagabine, 5-20 mg/kg i.p.) and 1-[2-[[(diphenylmethylene) imino]oxy]ethyl]-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride (NNC-711, 1-10 mg/kg i.p.) significantly reduced the severity of dystonia. These data suggest that GABA uptake inhibitors may provide novel therapeutic approaches for paroxysmal dyskinesias. |
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Authors:
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Annette Kreil; Angelika Richter |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2005-09-23 |
Journal Detail:
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Title: European journal of pharmacology Volume: 521 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-10-11 Completed Date: 2006-01-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 95-8 Citation Subset: IM |
Affiliation:
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Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universität (FU) Berlin, Koserstr. 20, D-14195 Berlin, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cricetinae Disease Progression Dose-Response Relationship, Drug Dystonia / genetics, pathology, prevention & control* Female GABA Antagonists / administration & dosage, therapeutic use* Injections, Intraperitoneal Male Mutation Nipecotic Acids / administration & dosage, therapeutic use Oximes / administration & dosage, therapeutic use Random Allocation Severity of Illness Index Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/GABA Antagonists; 0/Nipecotic Acids; 0/Oximes; 115103-54-3/tiagabine; 145645-62-1/NNC 711; 498-95-3/nipecotic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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