Document Detail

Antidystonic efficacy of gamma-aminobutyric acid uptake inhibitors in the dtsz mutant.
MedLine Citation:
PMID:  16183056     Owner:  NLM     Status:  MEDLINE    
In the dtsz mutant hamster, a model of paroxysmal dyskinesia in which dystonic episodes occur in response to stress, previous studies suggested that retarded development of gamma-aminobutyric acid (GABA)ergic inhibition plays a critical role in the pathogenesis. In the present study, we therefore examined the effects of selective GABA uptake inhibitors on severity of dystonia in dtsz hamsters. R(-)N-(4,4-di(3-methylthien-2-yl)-but-3-enyl) nipecotic acid hydrochloride (tiagabine, 5-20 mg/kg i.p.) and 1-[2-[[(diphenylmethylene) imino]oxy]ethyl]-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride (NNC-711, 1-10 mg/kg i.p.) significantly reduced the severity of dystonia. These data suggest that GABA uptake inhibitors may provide novel therapeutic approaches for paroxysmal dyskinesias.
Annette Kreil; Angelika Richter
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-09-23
Journal Detail:
Title:  European journal of pharmacology     Volume:  521     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-11     Completed Date:  2006-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  95-8     Citation Subset:  IM    
Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universität (FU) Berlin, Koserstr. 20, D-14195 Berlin, Germany.
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MeSH Terms
Disease Progression
Dose-Response Relationship, Drug
Dystonia / genetics,  pathology,  prevention & control*
GABA Antagonists / administration & dosage,  therapeutic use*
Injections, Intraperitoneal
Nipecotic Acids / administration & dosage,  therapeutic use
Oximes / administration & dosage,  therapeutic use
Random Allocation
Severity of Illness Index
Time Factors
Treatment Outcome
Reg. No./Substance:
0/GABA Antagonists; 0/Nipecotic Acids; 0/Oximes; 115103-54-3/tiagabine; 145645-62-1/NNC 711; 498-95-3/nipecotic acid

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