Document Detail


Antidyslipidemic activity of Indigofera tinctoria.
MedLine Citation:
PMID:  17594987     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Indigofera tinctoria is a perennial shrub, which belongs to the family Papilionaceae. As a part of our drug discovery program we have investigated the antidyslipidemic activity of the alcoholic extract from Indigofera tinctoria as well as its three other components, that is, chloroform, butanol and aqueous fractions in dyslipidemic hamsters that were fed a high fat diet. The chloroform fraction showed a significant decrease in the plasma triglycerides (TG, 52%) (P < 0.001), total cholesterol (TC, 29%) (P < 0.05), glycerol (Gly, 24%) and free fatty acids (FFA, 14%). This decrease was also accompanied by an increase in high density lipoproteins (HDL) by 9% and an increased HDL-C/TC ratio of 52% at the dose of 250 mg/kg of body weight.
Authors:
Anju Puri; Tanvir Khaliq; S M Rajendran; Geetika Bhatia; Ramesh Chandra; Tadigoppula Narender
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of herbal pharmacotherapy     Volume:  7     ISSN:  1522-8940     ISO Abbreviation:  J Herb Pharmacother     Publication Date:  2007  
Date Detail:
Created Date:  2007-06-27     Completed Date:  2007-10-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888586     Medline TA:  J Herb Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  59-64     Citation Subset:  IM    
Affiliation:
Biochemistry Division of CDRI, Lucknow, India.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Antilipemic Agents / administration & dosage*,  chemistry,  isolation & purification
Butanols / administration & dosage*,  chemistry
Chloroform / administration & dosage*,  chemistry
Cholesterol / metabolism
Cholesterol Esters / metabolism
Cholesterol, LDL / metabolism
Cricetinae
Dietary Fats
Dose-Response Relationship, Drug
Glycerol / metabolism
Indigofera / chemistry*
Lipoproteins, HDL / metabolism
Male
Plant Extracts / administration & dosage
Plants, Medicinal / chemistry
Triglycerides / metabolism
Chemical
Reg. No./Substance:
0/Antilipemic Agents; 0/Butanols; 0/Cholesterol Esters; 0/Cholesterol, LDL; 0/Dietary Fats; 0/HDL cholesteryl ester; 0/Lipoproteins, HDL; 0/Plant Extracts; 0/Triglycerides; 56-81-5/Glycerol; 57-88-5/Cholesterol; 67-66-3/Chloroform

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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