| Antidiuretic hormone responses to eucapnic and hypocapnic hypoxia in humans. | |
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MedLine Citation:
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PMID: 6818199 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Urinary excretion rate of antidiuretic hormone (UADHV) was studied in male volunteers in response to hypobaric hypoxia. The first series consisted of three groups. The chamber was decompressed to 465, 495, and 438 Torr during high-altitude (HA) exposure for groups I (n = 5), II (n = 5), and III (n = 4), respectively. In group I, the chamber air contained 3.77% CO2 to prevent alkalosis. The level of hypoxemia was similar in groups I and II. Mean 24-h UADHV was unchanged in group I, but increased 96% (P less than 0.05) and 180% (P less than 0.05) in groups II and III, respectively, on day 1 at HA and was normal during subsequent days at HA regardless of symptoms of acute mountain sickness. Shorter sampling intervals employed in a second series of experiments conducted at 495 Torr revealed a twofold increase in UADHV (P less than 0.05) 8-12 h after ascent in eight asymptomatic subjects; UADHV returned to base line within 9 h and remained low. The symptomatic subjects both had increased UADHV (3- and 8-fold from base line) between 2 and 4 h after ascent. Increased UADHV in asymptomatic subjects may be a result of the concomitant decrease in plasma volume, both of which appeared to be eliminated by CO2 supplementation. |
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Authors:
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J R Claybaugh; C E Wade; A K Sato; S A Cucinell; J C Lane; J T Maher |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of applied physiology: respiratory, environmental and exercise physiology Volume: 53 ISSN: 0161-7567 ISO Abbreviation: J Appl Physiol Publication Date: 1982 Oct |
Date Detail:
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Created Date: 1983-03-11 Completed Date: 1983-03-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7801242 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 815-23 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anoxia / physiopathology*, urine Blood Pressure Carbon Dioxide / blood* Humans Kidney / blood supply, physiopathology* Male Potassium / urine Regional Blood Flow Sodium / urine Time Factors Vasopressins / urine* |
| Chemical | |
Reg. No./Substance:
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11000-17-2/Vasopressins; 124-38-9/Carbon Dioxide; 7440-09-7/Potassium; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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