Document Detail

Antidiuretic hormone responses to eucapnic and hypocapnic hypoxia in humans.
MedLine Citation:
PMID:  6818199     Owner:  NLM     Status:  MEDLINE    
Urinary excretion rate of antidiuretic hormone (UADHV) was studied in male volunteers in response to hypobaric hypoxia. The first series consisted of three groups. The chamber was decompressed to 465, 495, and 438 Torr during high-altitude (HA) exposure for groups I (n = 5), II (n = 5), and III (n = 4), respectively. In group I, the chamber air contained 3.77% CO2 to prevent alkalosis. The level of hypoxemia was similar in groups I and II. Mean 24-h UADHV was unchanged in group I, but increased 96% (P less than 0.05) and 180% (P less than 0.05) in groups II and III, respectively, on day 1 at HA and was normal during subsequent days at HA regardless of symptoms of acute mountain sickness. Shorter sampling intervals employed in a second series of experiments conducted at 495 Torr revealed a twofold increase in UADHV (P less than 0.05) 8-12 h after ascent in eight asymptomatic subjects; UADHV returned to base line within 9 h and remained low. The symptomatic subjects both had increased UADHV (3- and 8-fold from base line) between 2 and 4 h after ascent. Increased UADHV in asymptomatic subjects may be a result of the concomitant decrease in plasma volume, both of which appeared to be eliminated by CO2 supplementation.
J R Claybaugh; C E Wade; A K Sato; S A Cucinell; J C Lane; J T Maher
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  53     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  815-23     Citation Subset:  IM    
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MeSH Terms
Anoxia / physiopathology*,  urine
Blood Pressure
Carbon Dioxide / blood*
Kidney / blood supply,  physiopathology*
Potassium / urine
Regional Blood Flow
Sodium / urine
Time Factors
Vasopressins / urine*
Reg. No./Substance:
11000-17-2/Vasopressins; 124-38-9/Carbon Dioxide; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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