| Antidiphtheria antibody responses in patients and carriers of Corynebacterium diphtheriae in the Arkhangelsk region of Russia. | |
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MedLine Citation:
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PMID: 16760319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diphtheria is under control in industrialized countries. However, single cases and outbreaks still occur and the disease is not completely understood. Forty-three individuals suspected of having diphtheria who were referred to the Infectious Disease Hospital of Arkhangelsk from December 1994 to March 1995 were included in this study. Fifteen patients were diagnosed as having diphtheria and received equine hyperimmune antidiphtheria toxin antiserum, and 28 were diagnosed as carriers, 12 with nondiphtherial tonsillitis or pharyngitis and 16 without symptoms. Serum samples were obtained on admission and during the course of the disease or during follow-up of carrier status. Samples were analyzed for antibodies against diphtheria toxin with both an in vitro neutralization test (NT) and a human-specific enzyme immunoassay. All of the cases but one were confirmed by a positive culture. Twelve patients had pharyngeal diphtheria, and three had combined laryngeal and pharyngeal disease. Half of the patients had life-threatening disease, and one died. On admission, the median antibody titers measured with the NT were 0.085 IU/ml for the patients, 5.12 IU/ml for the symptomatic carriers, and 10.24 IU/ml for the healthy carriers. All of the diphtheria patients but one and nine of the carriers (six symptomatic and three healthy) had increased antibody levels during the first 7 to 10 days after admission. No obvious correlation was revealed between the antibody level or its kinetics and the course of the disease. Antibody levels on admission of >1 IU/ml were associated with a low risk of diphtheria. |
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Authors:
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Elena Danilova; Pål A Jenum; Vegard Skogen; Valentin F Pilnikov; Haakon Sjursen |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: Clinical and vaccine immunology : CVI Volume: 13 ISSN: 1556-6811 ISO Abbreviation: Clin. Vaccine Immunol. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-08 Completed Date: 2006-08-04 Revised Date: 2010-09-15 |
Medline Journal Info:
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Nlm Unique ID: 101252125 Medline TA: Clin Vaccine Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 627-32 Citation Subset: IM |
Affiliation:
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Institute of Medicine, University of Bergen, Bergen, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antibodies, Bacterial / therapeutic use* Carrier State / epidemiology, immunology*, microbiology, therapy Child Child, Preschool Corynebacterium diphtheriae* Diphtheria / epidemiology, immunology*, microbiology, therapy* Diphtheria Toxin / immunology Enzyme-Linked Immunosorbent Assay / methods Female Follow-Up Studies Humans Male Middle Aged Retrospective Studies Russia / epidemiology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Diphtheria Toxin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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