| Antidiarrheal activity of Pterocarpus erinaceus methanol leaf extract in experimentally-induced diarrhea. | |
| | |
MedLine Citation:
|
PMID: 22221760 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate the antidiarrheal activity of the methanol leaf extract of Pterocarpus erinaceus in vivo. METHODS: The methanol leaf extract of Pterocarpus erinaceus was evaluated using different doses (100, 200 and 400 mg/kg body weight) orally for antidiarrheal activity using castor oil-induced diarrhea, charcoal meal transit time and castor oil-induced enteropooling in different groups of albino Wistar mice. The activity of the extract at different doses were compared to diphenoxylate (5 mg/kg) and atropine sulphate (3 mg/kg) which were used as standard reference drugs and also to the distilled water administered negative control group of mice. RESULTS: The extract at the doses used caused a significant (P< 0.01) reduction in the wet faeces passed by the mice in the castor oil-induced diarrhea, decreased the distance travelled by the charcoal meal by up to 54.8% and also caused a dose dependent and significant (P< 0.001) reduction in the intraluminal fluid accumulation in the castor oil-induced enteropooling. CONCLUSIONS: Our results indicate that Pterocarpus erinaceus extract produced significant antidiarrheal activity and the action may attribute to inhibition of gastrointestinal movement and fluid secretion. |
| | |
Authors:
|
I Maxwell Ezeja; Ihechiluru I Ezeigbo; Kelechi G Madubuike; Nkiru E Udeh; Iheanacho A Ukweni; Stella C Akomas; Daniel C Ifenkwe |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Asian Pacific journal of tropical medicine Volume: 5 ISSN: 1995-7645 ISO Abbreviation: Asian Pac J Trop Med Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-01-06 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101533720 Medline TA: Asian Pac J Trop Med Country: Singapore |
Other Details:
|
Languages: eng Pagination: 147-50 Citation Subset: IM |
Copyright Information:
|
Copyright © 2012 Hainan Medical College. Published by Elsevier B.V. All rights reserved. |
Affiliation:
|
Department of Veterinary Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antibacterial potential of sponge endosymbiont marine Enterobacter sp at Kavaratti Island, Lakshadwe...
Next Document: Eysenck personality and psychosocial status of adult patients with malocclusion.