| Antidiabetic and haematinic effects of Parquetina nigrescens on alloxan induced type-1 diabetes and normocytic normochromic anaemia in Wistar rats. | |
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MedLine Citation:
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PMID: 21327140 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The plant, Parquetina nigrescens is used in folklore medicine to treat diabetes mellitus and its complications in several parts of West Africa. OBJECTIVE: To determine the effect of Parquetina nigrescens extract on fasting blood glucose in alloxan-induced diabetic rats. METHODS: The blood glucose levels, complete blood count, erythrocyte indices and osmotic fragility, body and organ weights were evaluated. RESULTS: Diabetic rats treated with the extract showed significant (P<0.01) reduction of the blood glucose to levels comparable to that of the non-diabetic control and those treated with chlorpropamide (standard drug). Similarly, there was significant (P<0.01) reduction in the complete blood count in the diabetic rats. DISCUSSION: The anaemia, leucopenia and thrombocytopenia associated with the diabetes were corrected in the animals treated with the extract and chlorpropamide. The extract also reduced the erythrocyte osmotic fragility, body and organ weights. Parquetina nigrescens demonstrated antidiabetic property by reducing the elevated blood glucose in alloxan treated rats which is comparable to animals that received the standard drug. CONCLUSION: Paraquetina nigrescens stabilized the erythrocyte membrane, decreased the body weight probably by lowering lipogenesis. However, the mechanism underlying the antidiabetic and haematinic properties of Parquetina nigrescens remains to be elucidated. |
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Authors:
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A B Saba; A A Oyagbemi; O I Azeez |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: African health sciences Volume: 10 ISSN: 1729-0503 ISO Abbreviation: Afr Health Sci Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2011-02-17 Completed Date: 2011-04-27 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 101149451 Medline TA: Afr Health Sci Country: Uganda |
Other Details:
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Languages: eng Pagination: 276-82 Citation Subset: IM |
Affiliation:
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Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Nigeria. sabadee2000@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alloxan Anemia / drug therapy* Animals Apocynaceae / chemistry* Blood Glucose / drug effects* Diabetes Mellitus, Experimental / blood, drug therapy* Hematinics* / pharmacology, therapeutic use Hypoglycemic Agents* / isolation & purification, pharmacology, therapeutic use Osmotic Fragility Phytotherapy Plant Extracts* / isolation & purification, pharmacology, therapeutic use Plant Leaves Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hematinics; 0/Hypoglycemic Agents; 0/Plant Extracts; 50-71-5/Alloxan |
| Comments/Corrections | |
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