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Antidiabetic activity of gossypin, a pentahydroxyflavone glucoside in streptozotocin-induced experimental diabetes in rats.
MedLine Citation:
PMID:  21722326     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:  Most of the currently available oral hypoglycemic drugs for the treatment of diabetes mellitus elicit detrimental side effects. Hence search for plant derived products for the treatment of diabetes continues. Gossypin, a pentahydroxy flavone glucoside found rich in the flowers of Hibiscus vitifolius, possess many biological properties including antioxidant, anti-inflammatory and anticancer. The present study was aimed to evaluate the role of gossypin in streptozotocin- induced experimental diabetes in rats. Methods:  Diabetic rats were orally treated with gossypin for 30 days. OGTT was performed in all groups of rats. The levels of blood glucose, plasma insulin, hemoglobin and glycosylated haemoglobin were analysed. The level of glycogen content in liver and muscles were determined. Plasma protein and blood urea were also estimated. Results:  Oral administration of gossypin to diabetic rats showed an improved glucose tolerance. The increased levels of blood glucose, glycosylated hemoglobin and reduced levels of plasma insulin and hemoglobin observed in diabetic rats were significantly reverted to near normal after oral administration of gossypin. The levels of glycogen content in liver and muscles were significantly improved upon treatment with gossypin when compared with diabetic rats. Further, oral administration of gossypin to diabetic rats normalized the levels of plasma protein and blood urea. The obtained data were comparable with gliclazide, a standard reference drug for diabetes. Conclusions:  The results of the present study indicate that gossypin has potent antidiabetic activity in streptozotocin-induced experimental diabetes in rats.
Authors:
Venkatesan Thamizhiniyan; Sorimuthu Pillai Subramanian
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-1
Journal Detail:
Title:  Journal of diabetes     Volume:  -     ISSN:  1753-0407     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101504326     Medline TA:  J Diabetes     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Ruijin Hospital and Blackwell Publishing Asia Pty Ltd.
Affiliation:
Department of Biochemistry, University of Madras, Guindy campus, Chennai - 600 025, Tamilnadu, India.
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