| Antidiabetic activity of Passiflora incarnata Linn. in streptozotocin-induced diabetes in mice. | |
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MedLine Citation:
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PMID: 22212504 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: The present study was designed to investigate the hypoglycemic and hypolipidemic properties of Passiflora incarnata Linn. leaves which are widely used as traditional treatment for diabetes mellitus. MATERIALS AND METHODS: The methanolic extracts of leaves of Passiflora incarnata were administered orally (100 and 200mg/kg, for 15 days) to streptozotocin-induced diabetic mice. Hypoglycemic effects, oral glucose tolerance test, change in body weight and lipid profile of diabetic mice treated with methanolic extracts were assessed and compared with normal, diabetic control and standard drug treated mice. Histological examination during 15 days of treatment was also carried out. RESULTS: Methanolic extract (200mg/kg) produced a significant reduction in fasting blood glucose level in streptozotocin-induced diabetic mice. Significant differences were also observed in urine glucose level, oral glucose tolerance test, serum lipid profile and body weight of methanolic extract treated diabetic mice, when compared with diabetic, normal and standard drug treated mice. Histopathological studies of the pancreas showed comparable regeneration of the cells by extract which were earlier necrosed by streptozotocin. CONCLUSION: Methanolic extract of Passiflora incarnata exhibit significant anti-hyperglycemic and hypolipidemic activities in streptozotocin-induced diabetes in mice. |
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Authors:
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Rakesh K Gupta; Dharmendra Kumar; Amrendra K Chaudhary; Mukesh Maithani; Ranjit Singh |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-28 |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: - ISSN: 1872-7573 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-1-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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School of Pharmaceutical Sciences, Shobhit University, Meerut 250110 (UP), India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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