Document Detail

Antidepressants and menstruation disorders in women: a cross-sectional study in three centers.
MedLine Citation:
PMID:  22534402     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The relationship between menstruation disorders and antidepressant drugs usage in women remains unclear. In this study, we aimed to investigate the incidence rate of antidepressant-related menstruation disorders and to examine whether or not antidepressant use is associated with menstrual disorders in women.
METHODS: The study sample was gathered from three centers and four hospitals. A total of 1432 women who met the criteria of inclusion were included in the study. The sample was divided into two groups: the antidepressant group (n=793) and the control group (n=639). The menstruation disorders were established with reports from the study participants on the basis of related gynecological descriptions.
RESULTS: The prevalence of menstrual disorders was significantly higher in the antidepressant group (24.6%) than the control group (12.2%). The incidence of antidepressant-induced menstruation disorder was 14.5%. The antidepressants most associated with menstrual disorders were paroxetine, venlafaxine, sertraline and their combination with mirtazapine. Overall, the incidence rate was similar in women receiving selective serotonin reuptake inhibitors and serotonin noradrenaline reuptake inhibitors.
CONCLUSIONS: The results of the present study suggest that menstruation disorders are frequently observed in women taking antidepressants and that it appears to be associated with antidepressant use at least in some women.
Faruk Uguz; Mine Sahingoz; Seyit Ali Kose; Ozgur Ozbebit; Cem Sengul; Yavuz Selvi; Ceyhan Balci Sengul; Medine Gıynas Ayhan; Adnan Dagistanli; Rustem Askin
Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study     Date:  2012-04-24
Journal Detail:
Title:  General hospital psychiatry     Volume:  34     ISSN:  1873-7714     ISO Abbreviation:  Gen Hosp Psychiatry     Publication Date:    2012 Sep-Oct
Date Detail:
Created Date:  2012-08-27     Completed Date:  2013-01-14     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  7905527     Medline TA:  Gen Hosp Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  529-33     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Department of Psychiatry, Meram Faculty of Medicine, Konya University, Konya, Turkey.
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MeSH Terms
Ambulatory Care
Antidepressive Agents / adverse effects*
Cross-Sectional Studies
Cyclohexanols / adverse effects
Menstruation Disturbances / chemically induced*,  epidemiology
Mianserin / adverse effects,  analogs & derivatives
Paroxetine / adverse effects
Qualitative Research
Sertraline / adverse effects
Turkey / epidemiology
Young Adult
Reg. No./Substance:
0/Antidepressive Agents; 0/Cyclohexanols; 24219-97-4/Mianserin; 61337-67-5/mirtazapine; 61869-08-7/Paroxetine; 79617-96-2/Sertraline; GRZ5RCB1QG/venlafaxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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