Document Detail

Antidepressants in concomitant chronic back pain and depression: doxepin and desipramine compared.
MedLine Citation:
PMID:  6321455     Owner:  NLM     Status:  MEDLINE    
Doxepin and desipramine at final doses of 188 and 173 mg/day, respectively, were compared in 36 volunteers with major affective or dysthymic disorder and chronic back pain. Both drugs produced significant decreases in depression, with an overall response rate of 70%; no significant difference was seen between groups. Pain ratings also decreased significantly in both groups (overall response rate = 50%); pain severity showed a better response to doxepin than to desipramine. While baseline pain, depression, and anxiety were correlated, treatment changes in these measures did not correlate. CSF beta-endorphin levels did not change with treatment. The usefulness of an antidepressant with anxiolytic properties, such as doxepin, is discussed.
N Ward; J A Bokan; M Phillips; C Benedetti; S Butler; D Spengler
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of clinical psychiatry     Volume:  45     ISSN:  0160-6689     ISO Abbreviation:  J Clin Psychiatry     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-04-24     Completed Date:  1984-04-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7801243     Medline TA:  J Clin Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  54-9     Citation Subset:  IM    
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MeSH Terms
Anxiety Disorders / drug therapy,  psychology
Back Pain / complications,  drug therapy*,  psychology
Chronic Disease
Clinical Trials as Topic
Depressive Disorder / complications,  drug therapy*,  psychology
Desipramine / administration & dosage,  therapeutic use*
Doxepin / administration & dosage,  therapeutic use*
Endorphins / cerebrospinal fluid
Helplessness, Learned / psychology
Personality Inventory
Psychiatric Status Rating Scales
Reg. No./Substance:
0/Endorphins; 0/Placebos; 1668-19-5/Doxepin; 50-47-5/Desipramine; 60617-12-1/beta-Endorphin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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