Document Detail


Antidepressants given repeatedly increase the behavioural effect of dopamine D-2 agonist.
MedLine Citation:
PMID:  2569028     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of single or repeated doses of antidepressant drugs (imipramine, amitriptyline, citalopram, mianserin) on rat locomotor hyperactivity induced by quinpirole, a dopamine D-2 receptor agonist, was investigated. Single doses of antidepressants do not change the effect of quinpirole, but enhance it when they are administered repeatedly. This enhancement is inhibited by (+/-)-sulpiride, a dopamine D-2 receptor antagonist. The results obtained indicate that the enhancement of dopaminergically-stimulated hyperactivity induced by repeated doses of antidepressants is mediated by dopamine D-2 receptors.
Authors:
J Maj; Z Rogóz; G Skuza; H Sowińska
Related Documents :
7751968 - Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes r...
7642168 - Recent aspect of the role of peripheral dopamine and its receptors in the pathogenesis ...
16719818 - The nmda/d1 receptor complex as a new target in drug development.
16012198 - Direct receptor cross-talk can mediate the modulation of excitatory and inhibitory neur...
22147258 - In vivo electrophysiological and neurochemical effects of the selective 5-ht(1a) recept...
20064718 - Remote functionalization of sch 39166: discovery of potent and selective benzazepine do...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neural transmission. General section     Volume:  78     ISSN:  -     ISO Abbreviation:  J. Neural Transm. Gen. Sect.     Publication Date:  1989  
Date Detail:
Created Date:  1989-09-07     Completed Date:  1989-09-07     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9002201     Medline TA:  J Neural Transm Gen Sect     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amitriptyline / pharmacology
Animals
Antidepressive Agents / pharmacology*
Citalopram / pharmacology
Dopamine Agents / metabolism*
Ergolines / metabolism*
Locomotion / drug effects*
Male
Mianserin / pharmacology
Quinpirole
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Antidepressive Agents; 0/Dopamine Agents; 0/Ergolines; 0DHU5B8D6V/Citalopram; 1806D8D52K/Amitriptyline; 20OP60125T/Quinpirole; 250PJI13LM/Mianserin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A novel subset of CD2-, CD3/T cell receptor alpha/beta+ human peripheral blood T cells. Phenotypic a...
Next Document:  Effects of intrastriatal blockade of glutamatergic transmission on the acquisition of T-maze and rad...