Document Detail

Antidepressants given repeatedly increase the behavioural effect of dopamine D-2 agonist.
MedLine Citation:
PMID:  2569028     Owner:  NLM     Status:  MEDLINE    
The effects of single or repeated doses of antidepressant drugs (imipramine, amitriptyline, citalopram, mianserin) on rat locomotor hyperactivity induced by quinpirole, a dopamine D-2 receptor agonist, was investigated. Single doses of antidepressants do not change the effect of quinpirole, but enhance it when they are administered repeatedly. This enhancement is inhibited by (+/-)-sulpiride, a dopamine D-2 receptor antagonist. The results obtained indicate that the enhancement of dopaminergically-stimulated hyperactivity induced by repeated doses of antidepressants is mediated by dopamine D-2 receptors.
J Maj; Z Rogóz; G Skuza; H Sowińska
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neural transmission. General section     Volume:  78     ISSN:  -     ISO Abbreviation:  J. Neural Transm. Gen. Sect.     Publication Date:  1989  
Date Detail:
Created Date:  1989-09-07     Completed Date:  1989-09-07     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9002201     Medline TA:  J Neural Transm Gen Sect     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
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MeSH Terms
Amitriptyline / pharmacology
Antidepressive Agents / pharmacology*
Citalopram / pharmacology
Dopamine Agents / metabolism*
Ergolines / metabolism*
Locomotion / drug effects*
Mianserin / pharmacology
Rats, Inbred Strains
Reg. No./Substance:
0/Antidepressive Agents; 0/Dopamine Agents; 0/Ergolines; 0DHU5B8D6V/Citalopram; 1806D8D52K/Amitriptyline; 20OP60125T/Quinpirole; 250PJI13LM/Mianserin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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