Document Detail

Antidepressants: can we determine how quickly they work? Issues from the literature.
MedLine Citation:
PMID:  7675984     Owner:  NLM     Status:  MEDLINE    
Published reports of antidepressants in clinical trials were reviewed by conducting a literature search focusing on the time period between 1969 and 1994; 240 English-language articles were identified. In these, considerable variation was noted in how study data were evaluated. A few particular points of view concerning antidepressant speed of onset were abstracted. These demonstrate that both antidepressant and placebo treatment of depressed patients are associated with measurable clinical activity during the first weeks of therapy. Methods currently exist to determine speed of antidepressant onset. However, at least one proposed method (Quitkin's pattern analysis) has not yet identified any fast-acting antidepressants. Further work is needed to refine the methods of studying antidepressant onset of action. It is most important that antidepressant drugs with early, clinically relevant onset of activity be identified.
A T Derivan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Psychopharmacology bulletin     Volume:  31     ISSN:  0048-5764     ISO Abbreviation:  Psychopharmacol Bull     Publication Date:  1995  
Date Detail:
Created Date:  1995-10-17     Completed Date:  1995-10-17     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0101123     Medline TA:  Psychopharmacol Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  23-8     Citation Subset:  IM    
Wyeth-Ayerst Laboratories, Radnor, PA 19087, USA.
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MeSH Terms
Antidepressive Agents / therapeutic use*
Depressive Disorder / drug therapy*
Time Factors
Reg. No./Substance:
0/Antidepressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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