| Antidepressants: can we determine how quickly they work? Issues from the literature. | |
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MedLine Citation:
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PMID: 7675984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Published reports of antidepressants in clinical trials were reviewed by conducting a literature search focusing on the time period between 1969 and 1994; 240 English-language articles were identified. In these, considerable variation was noted in how study data were evaluated. A few particular points of view concerning antidepressant speed of onset were abstracted. These demonstrate that both antidepressant and placebo treatment of depressed patients are associated with measurable clinical activity during the first weeks of therapy. Methods currently exist to determine speed of antidepressant onset. However, at least one proposed method (Quitkin's pattern analysis) has not yet identified any fast-acting antidepressants. Further work is needed to refine the methods of studying antidepressant onset of action. It is most important that antidepressant drugs with early, clinically relevant onset of activity be identified. |
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Authors:
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A T Derivan |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Psychopharmacology bulletin Volume: 31 ISSN: 0048-5764 ISO Abbreviation: Psychopharmacol Bull Publication Date: 1995 |
Date Detail:
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Created Date: 1995-10-17 Completed Date: 1995-10-17 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0101123 Medline TA: Psychopharmacol Bull Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 23-8 Citation Subset: IM |
Affiliation:
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Wyeth-Ayerst Laboratories, Radnor, PA 19087, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antidepressive Agents
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therapeutic use* Depressive Disorder / drug therapy* Humans Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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