Document Detail


Antidepressants may mitigate the effects of prenatal maternal anxiety on infant auditory sensory gating.
MedLine Citation:
PMID:  22581104     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Prenatal maternal anxiety has detrimental effects on the offspring's neurocognitive development, including impaired attentional function. Antidepressants are commonly used during pregnancy, yet their impact on offspring attention and their interaction with maternal anxiety has not been assessed. The authors used P50 auditory sensory gating, a putative marker of early attentional processes measurable in young infants, to assess the impact of maternal anxiety and antidepressant use.
METHOD: A total of 242 mother-infant dyads were classified relative to maternal history of anxiety and maternal prenatal antidepressant use. Infant P50 auditory sensory gating was recorded during active sleep at a mean age of 76 days (SD=38).
RESULTS: In the absence of prenatal antidepressant exposure, infants whose mothers had a history of anxiety diagnoses had diminished P50 sensory gating. Prenatal antidepressant exposure mitigated the effect of anxiety. The effect of maternal anxiety was limited to amplitude of response to the second stimulus, while antidepressant exposure had an impact on the amplitude of response to both the first and second stimulus.
CONCLUSIONS: Maternal anxiety disorders are associated with less inhibition during infant sensory gating, a performance deficit mitigated by prenatal antidepressant exposure. This effect may be important in considering the risks and benefits of antidepressant use during pregnancy. Cholinergic mechanisms are hypothesized for both anxiety and antidepressant effects, although the cholinergic receptors involved are likely different for anxiety and antidepressant effects.
Authors:
Sharon K Hunter; Jordan H Mendoza; Kimberly D'Anna; Gary O Zerbe; Lizbeth McCarthy; Camille Hoffman; Robert Freedman; Randal G Ross
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  169     ISSN:  1535-7228     ISO Abbreviation:  Am J Psychiatry     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-12     Completed Date:  2012-08-16     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  616-24     Citation Subset:  AIM; IM    
Affiliation:
Department of Psychiatry, University of Colorado Denver, Aurora, USA.
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation / psychology
Adult
Antidepressive Agents / therapeutic use*
Anxiety Disorders / complications,  drug therapy*
Evoked Potentials, Auditory / physiology
Female
Humans
Infant
Male
Pregnancy
Pregnancy Complications / drug therapy,  psychology*
Prenatal Care / methods
Prenatal Exposure Delayed Effects / physiopathology
Sensory Gating / drug effects*,  physiology
Grant Support
ID/Acronym/Agency:
K12 HD001271/HD/NICHD NIH HHS; K12HD001271/HD/NICHD NIH HHS; P50 MH086383/MH/NIMH NIH HHS; P50MH086383/MH/NIMH NIH HHS; R01 MH056539/MH/NIMH NIH HHS; R01MH056539/MH/NIMH NIH HHS; R25 MH080859/MH/NIMH NIH HHS; R25MH080859/MH/NIMH NIH HHS; T32 MH015442/MH/NIMH NIH HHS; T32MH015442/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Antidepressive Agents
Comments/Corrections
Comment In:
Am J Psychiatry. 2012 Jun;169(6):554-6   [PMID:  22684589 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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