Document Detail

Antidepressants and bleeding risk after face-lift surgery.
MedLine Citation:
PMID:  22801798     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the rate of post-face-lift hematoma among users of serotonin reuptake inhibitors (SSRIs) vs non-SSRI users. Selective serotonin reuptake inhibitors have come under recent scrutiny because of possible bleeding risks. However, cessation of SSRIs carries inherent risks.
METHODS: The medical charts for 250 consecutive patients who underwent a modified deep-plane face-lift and 13 patients who underwent neck-lift from January 2010 to May 2011 were reviewed for the incidence of postoperative hematoma. Patients' medical records were examined for medical comorbidities, coagulopathy, and medication list, with particular attention to any usage of SSRIs or serotonin norepinephrine reuptake inhibitors (SNRIs).
RESULTS: Twenty-two percent of patients were taking SSRIs or SNRIs. We observed a total hematoma (major + minor) rate of 1.95% for non-SSRI/SNRI users vs 1.72% for SSRI/SNRI users. The minor hematoma rate was 1.95% among nonusers vs 0% for users. The major hematoma rate was 0% among nonusers vs 1.72% for users.
CONCLUSIONS: Usage of SSRIs was more common in this large series of face-lift patients than in the general population. In these patients, SSRIs in the perioperative period are found to be safe and did not seem to adversely affect outcome. We found no evidence to support discontinuing SSRIs perioperatively.
Sanaz Harirchian; Richard A Zoumalan; David B Rosenberg
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of facial plastic surgery     Volume:  14     ISSN:  1538-3660     ISO Abbreviation:  Arch Facial Plast Surg     Publication Date:    2012 Jul-Aug
Date Detail:
Created Date:  2012-07-17     Completed Date:  2012-11-05     Revised Date:  2012-11-09    
Medline Journal Info:
Nlm Unique ID:  100883500     Medline TA:  Arch Facial Plast Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  248-52     Citation Subset:  IM    
Department of Otolaryngology–Head and Neck Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA.
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MeSH Terms
Age Distribution
Aged, 80 and over
Antidepressive Agents / administration & dosage,  adverse effects*
Case-Control Studies
Follow-Up Studies
Hematoma / chemically induced*,  epidemiology,  etiology
Hemorrhage / chemically induced,  epidemiology,  etiology
Middle Aged
Reference Values
Retrospective Studies
Rhytidoplasty / adverse effects*,  methods
Risk Assessment
Serotonin Uptake Inhibitors / adverse effects*,  therapeutic use
Severity of Illness Index
Sex Distribution
Treatment Outcome
Reg. No./Substance:
0/Antidepressive Agents; 0/Serotonin Uptake Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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