Document Detail

Antidepressant use during pregnancy: the benefit-risk ratio.
MedLine Citation:
PMID:  22425404     Owner:  NLM     Status:  MEDLINE    
Antidepressants are used commonly in pregnancy. Physicians who provide health care for pregnant women with depression must balance maternal well-being with potential fetal risks of these medications. Over the last decade, scores of original and review articles have discussed whether selective serotonin reuptake inhibitors-selective serotonin norepinephrine reuptake inhibitors possess risks to the fetus; however, very little has been done to integrate these potential risks, if they exist, into an overall context of a benefit:risk ratio. This review aims at presenting an updated analysis of fetal and maternal exposure to selective serotonin or norepinephrine reuptake inhibitors to allow an evidence-based benefit:risk ratio. When a psychiatric condition necessitates pharmacotherapy, the benefits of such therapy far outweigh the potential minimal risks of cardiac malformations, primary pulmonary hypertension of the newborn infant, or poor neonatal adaptation syndrome.
Gideon Koren; Hedvig Nordeng
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-02-21
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  207     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-03     Completed Date:  2012-11-13     Revised Date:  2012-12-21    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  157-63     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
Motherisk Program, Division of Clinical Pharmacology/Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada.
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MeSH Terms
Abnormalities, Drug-Induced / etiology
Antidepressive Agents / adverse effects,  therapeutic use*
Depression / drug therapy*
Fetal Diseases / chemically induced
Odds Ratio
Pregnancy Complications / drug therapy*
Risk Assessment
Reg. No./Substance:
0/Antidepressive Agents
Comment In:
Am J Obstet Gynecol. 2012 Nov;207(5):e10-1; author reply e11   [PMID:  22917485 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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