Document Detail

Antidepressant medication reverses increased sensitivity to light in depression: preliminary report.
MedLine Citation:
PMID:  2748876     Owner:  NLM     Status:  MEDLINE    
1. Sensitivity to blue light was quantified using a Friedman Central Field Analyzer and the Dark Adaptation Threshold procedure. 2. Patients diagnosed as having a major depressive disorder using research diagnostic criteria had dark adaptation thresholds quantified after a 10 day drug wash out and again after antidepressant drug therapy. 3. Prior to drug treatment patients were significantly more sensitive to light than controls as measured by cone but not rod thresholds. 4. Following drug treatment both cone and rod thresholds were reduced in patients. In comparison to controls, drug treatment normalized cone threshold and reduced rod threshold in patients. 5. These data provide ophthalmological evidence for increased sensitivity to light in non medicated depressive disorder and a reduction in sensitivity following antidepressant drug therapy. 6. The possibility of altered retinal function and consequently the ability to perceive and use light for entrainment of circadian rhythm in affective disorder deserves further study.
J Seggie; C Canny; F Mai; E McCrank; E Waring
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  13     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  1989  
Date Detail:
Created Date:  1989-08-21     Completed Date:  1989-08-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  537-41     Citation Subset:  IM    
Department of Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
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MeSH Terms
Adaptation, Ocular / drug effects
Antidepressive Agents / therapeutic use*
Depressive Disorder / drug therapy,  physiopathology*
Middle Aged
Photosensitivity Disorders / drug therapy*,  etiology
Reference Values
Retina / drug effects,  physiology,  physiopathology*
Reg. No./Substance:
0/Antidepressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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