Document Detail


Antidepressant-like effects of rosiglitazone, a PPARγ agonist, in the rat forced swim and mouse tail suspension tests.
MedLine Citation:
PMID:  19745723     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Several studies have evaluated thiazolidinedione therapy as medical treatments for some central nervous system disorders, such as cognitive deficits associated with neurodegenerative disorders. However, there is limited data to support a direct role for peroxisome proliferator-activated receptor-γ agonists in depression. Therefore, the aim of this study was to investigate antidepressant-like activity of rosiglitazone using the mouse tail suspension test and the rat forced swimming test, two models sensitive to the effects of antidepressants. In the tail suspension test, 5 days of treatment with rosiglitazone (8.5 or 17 mg/kg, orally) reduced immobility time. In the forced swimming test, rosiglitazone (6 or 12 mg/kg, orally) treatment decreased immobility time and increased climbing. These effects were not accompanied by any alteration in locomotor activity in the open field test. Rosiglitazone treatment (6 or 12 mg/kg, orally) significantly reduced plasma corticosterone levels in rats. GW9662 significantly inhibited the rosiglitazone-induced reduction in the duration of immobility. In summary, this study suggests that rosiglitazone possesses a specific antidepressant-like activity in behavioral models and that this effect may be mediated by reduction of plasma corticosterone level.
Authors:
Amany Ali Eissa Ahmed; Nawal Mohammed Al-Rasheed; Nouf Mohammed Al-Rasheed
Related Documents :
22473453 - Non-invasive in vivo detection of peripheral limb ischemia improvement in the rat after...
23005263 - Effects of ρ-da1a a peptidic α(1) (a) -adrenoceptor antagonist in human isolated pros...
11211923 - Oral beta-stimulants can inhibit passive cutaneous anaphylaxis in rats through an indir...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioural pharmacology     Volume:  20     ISSN:  1473-5849     ISO Abbreviation:  Behav Pharmacol     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2010-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013016     Medline TA:  Behav Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  635-42     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Sex and cannabinoid CB1 genotype differentiate palatable food and cocaine self-administration behavi...
Next Document:  Home blood pressure has a stronger association with arterial stiffness than clinic blood pressure: t...