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Antidepressant-like effect of riparin II from Aniba riparia in mice: evidence for the involvement of the monoaminergic system.
MedLine Citation:
PMID:  21854446     Owner:  NLM     Status:  Publisher    
In a previous study conducted by our group, riparin II (ripII) isolated from the green fruit of Aniba riparia presented antianxiety effects in mice. This study investigates a possible antidepressant activity of rip II using two predictive tests for antidepressant activity in rodents: the forced swimming test (FST) and tail suspension test (TST). Additionally, the mechanisms involved in the antidepressant-like effect in mice were also assessed. Rip II was acute administered by intraperitoneal (i.p.) and oral (p.o) routes to male mice at doses of 25 and 50 mg/kg. Results showed that ripII at both tested doses and administration routes produced a significant decrease of immobility time in FST and TST. The pretreatment of mice with prazosin (1 mg/kg, i.p., an α1-adrenoceptor antagonist), SCH23390 (15 μg/kg, i.p., a dopamine D1 receptor antagonist), sulpiride (50 mg/kg, i.p., a dopamine D2 receptor antagonist), p-chlorophenylalanine (100 mg/kg, an inhibitor of serotonin synthesis), or NAN-190 (0.5 mg/kg, a serotonin 5-HT1A receptor antagonist) completely blocked the anti-immobility effects elicited by riparin II (50 mg/kg, p.o.) in the FST. This study indicates that riparin II produces significant antidepressant-like activity in the forced swimming and TSTs, and this effect seems to be dependent on its interaction with noradrenergic, dopaminergic, and serotonergic systems.
Caroline Porto Leite Teixeira; Carla Thiciane Vasconcelos de Melo; Fernando Luiz Oliveira de Araújo; Allyne Mara Rodrigues de Carvalho; Maria Izabel Gomes Silva; José Maria Barbosa-Filho; Danielle Silveira Macêdo; Glauce Socorro de Barros Viana; Francisca Cléa Florenço de Sousa
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-21
Journal Detail:
Title:  Fundamental & clinical pharmacology     Volume:  -     ISSN:  1472-8206     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710411     Medline TA:  Fundam Clin Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Author Fundamental and Clinical Pharmacology © 2011 Société Française de Pharmacologie et de Thérapeutique.
Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará: Rua Cel. Nunes de Melo 1127, 60430-270 Fortaleza, Brazil Laboratory of Pharmaceutics Technology, Federal University of Paraíba, João Pessoa, Brazil.
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