| Antidepressant-like effect of riparin II from Aniba riparia in mice: evidence for the involvement of the monoaminergic system. | |
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MedLine Citation:
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PMID: 21854446 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In a previous study conducted by our group, riparin II (ripII) isolated from the green fruit of Aniba riparia presented antianxiety effects in mice. This study investigates a possible antidepressant activity of rip II using two predictive tests for antidepressant activity in rodents: the forced swimming test (FST) and tail suspension test (TST). Additionally, the mechanisms involved in the antidepressant-like effect in mice were also assessed. Rip II was acute administered by intraperitoneal (i.p.) and oral (p.o) routes to male mice at doses of 25 and 50 mg/kg. Results showed that ripII at both tested doses and administration routes produced a significant decrease of immobility time in FST and TST. The pretreatment of mice with prazosin (1 mg/kg, i.p., an α1-adrenoceptor antagonist), SCH23390 (15 μg/kg, i.p., a dopamine D1 receptor antagonist), sulpiride (50 mg/kg, i.p., a dopamine D2 receptor antagonist), p-chlorophenylalanine (100 mg/kg, an inhibitor of serotonin synthesis), or NAN-190 (0.5 mg/kg, a serotonin 5-HT1A receptor antagonist) completely blocked the anti-immobility effects elicited by riparin II (50 mg/kg, p.o.) in the FST. This study indicates that riparin II produces significant antidepressant-like activity in the forced swimming and TSTs, and this effect seems to be dependent on its interaction with noradrenergic, dopaminergic, and serotonergic systems. |
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Authors:
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Caroline Porto Leite Teixeira; Carla Thiciane Vasconcelos de Melo; Fernando Luiz Oliveira de Araújo; Allyne Mara Rodrigues de Carvalho; Maria Izabel Gomes Silva; José Maria Barbosa-Filho; Danielle Silveira Macêdo; Glauce Socorro de Barros Viana; Francisca Cléa Florenço de Sousa |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-21 |
Journal Detail:
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Title: Fundamental & clinical pharmacology Volume: - ISSN: 1472-8206 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710411 Medline TA: Fundam Clin Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Author Fundamental and Clinical Pharmacology © 2011 Société Française de Pharmacologie et de Thérapeutique. |
Affiliation:
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Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará: Rua Cel. Nunes de Melo 1127, 60430-270 Fortaleza, Brazil Laboratory of Pharmaceutics Technology, Federal University of Paraíba, João Pessoa, Brazil. |
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