Document Detail

Antidepressant effect of three traditional Chinese medicines in the learned helplessness model.
MedLine Citation:
PMID:  15120459     Owner:  NLM     Status:  MEDLINE    
Plantago asiatica, Scrophularia ningpoensis and Ilex pubescens are among the traditional Chinese medicines which are more frequently prescribed for treating depression-like ailments in the past and present traditional Chinese medical practice. The present work was therefore conducted to evaluate the presumable antidepressant effects of the extracts derived from the three remedies in mice using the learned helplessness model being used for screening for antidepressant compounds in modern medicinal researches. As a result, the petroleum extracts of Plantago asiatica and Ilex pubescens as well as the EtOAc extract of Scrophularia ningpoensis and the petroleum-soluble fraction of the acidic hydrolysate of the water extract of Ilex pubescens (after petroleum extraction) decreased significantly the number of escape failures relative to the control. The finding rationalized the clinical prescription of the herbs for the treatment of depression, and shined a clue for the characterization of the antidepressant phytochemical(s).
Chen Xu; Lan Luo; Ren Xiang Tan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  91     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-05-03     Completed Date:  2004-08-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  345-9     Citation Subset:  IM    
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.
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MeSH Terms
Antidepressive Agents / administration & dosage,  pharmacology*,  therapeutic use
Behavior, Animal / drug effects*
Dose-Response Relationship, Drug
Drugs, Chinese Herbal / administration & dosage,  pharmacology*,  therapeutic use
Helplessness, Learned*
Mice, Inbred ICR
Plant Extracts / administration & dosage,  pharmacology,  therapeutic use
Plants, Medicinal*
Reg. No./Substance:
0/Antidepressive Agents; 0/Drugs, Chinese Herbal; 0/Plant Extracts

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