Document Detail

Anticonvulsant use during pregnancy.
MedLine Citation:
PMID:  3986865     Owner:  NLM     Status:  MEDLINE    
Although antiepileptic medications may play a role in fetal malformations, this risk appears no greater than the risk associated with either the seizures themselves or a change in medication during pregnancy. In general, the number and the dose of antiepileptic medications should be minimized during pregnancy. Potential complications during the pregnancy must be anticipated. Drug levels must be monitored. Because the fetus is at a somewhat higher risk, ultrasound studies may be useful in monitoring the pregnancy. Delivery should take place in a center where appropriate facilities are available if intervention is required during labor or if the baby is malformed. Both the infant and the mother should be monitored closely after the delivery.
D A Stumpf
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical therapeutics     Volume:  7     ISSN:  0149-2918     ISO Abbreviation:  Clin Ther     Publication Date:  1985  
Date Detail:
Created Date:  1985-06-06     Completed Date:  1985-06-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7706726     Medline TA:  Clin Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  258-65     Citation Subset:  IM    
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MeSH Terms
Abnormalities, Drug-Induced / etiology
Anticonvulsants / adverse effects*,  therapeutic use
Epilepsy / drug therapy*,  genetics
Fetal Death / chemically induced
Phenobarbital / adverse effects
Phenytoin / adverse effects
Pregnancy Complications / drug therapy*
Trimethadione / adverse effects
Reg. No./Substance:
0/Anticonvulsants; 127-48-0/Trimethadione; 50-06-6/Phenobarbital; 57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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