| Anticonvulsant properties of 3-hydroxy-2-quinoxalinecarboxylic acid, a newly found antagonist of excitatory amino acids. | |
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MedLine Citation:
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PMID: 2861099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Various aromatic acids have been investigated as putative ligands of excitatory amino acid receptors. 3-Hydroxy-2-quinoxalinecarboxylic acid (HQC), at 1 mM, was found to antagonize the 22Na+ efflux produced in 22Na+-preloaded brain slices by N-methyl-D-aspartate and kainate. The response to glutamate was also affected but not that to quisqualate. The apparent KI value of HQC for suppression of the N-methyl-D-aspartate response was 0.27 mM. The anticonvulsant action of HQC was investigated in mice and rats. HQC administered intracerebroventricularly caused a dose dependent delay in the occurrence of picrotoxin induced convulsions and afforded protection against picrotoxin induced death. These results confirm the proposition that antagonists of excitatory amino acids possess anticonvulsant properties. |
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Authors:
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U Erez; H Frenk; O Goldberg; A Cohen; V I Teichberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 110 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1985 Mar |
Date Detail:
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Created Date: 1985-07-31 Completed Date: 1985-07-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 31-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticonvulsants / pharmacology* Aspartic Acid / analogs & derivatives*, antagonists & inhibitors Electroencephalography Female Glutamates / antagonists & inhibitors* Glutamic Acid Kainic Acid / antagonists & inhibitors* Male Mice Mice, Inbred Strains N-Methylaspartate Picrotoxin Pyrrolidines / antagonists & inhibitors* Quinoxalines / pharmacology* Rats Rats, Inbred Strains Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter / drug effects Sodium / metabolism Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Glutamates; 0/Pyrrolidines; 0/Quinoxalines; 0/Receptors, N-Methyl-D-Aspartate; 0/Receptors, Neurotransmitter; 1204-75-7/3-hydroxy-2-quinoxalinecarboxylic acid; 124-87-8/Picrotoxin; 487-79-6/Kainic Acid; 56-84-8/Aspartic Acid; 56-86-0/Glutamic Acid; 6384-92-5/N-Methylaspartate; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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