Document Detail


Anticonvulsant effects of carbamazepine on spontaneous seizures in rats with kainate-induced epilepsy: comparison of intraperitoneal injections with drug-in-food protocols.
MedLine Citation:
PMID:  17711461     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The present study evaluated the effectiveness of intraperitoneal (IP) injections and oral administration of carbamazepine (CBZ) in food on the frequency of spontaneous motor seizures in rats with kainate-induced epilepsy. The purpose was to develop a convenient drug-in-food approach for continuous, long-term administration of potential antiepileptic drugs (AEDs). METHODS: Single IP injections of CBZ (10-100 mg/kg) were compared to vehicle injections via six AED-versus-vehicle tests using a repeated-measures, crossover protocol. Similar protocols were used with CBZ-containing or control food pellets. RESULTS: CBZ significantly reduced motor seizure frequency at 30 and 100 mg/kg after single IP injections, and these doses completely blocked motor seizures during a 6-h postdrug epoch in 25% and 70% of the animals, respectively. Single administrations of 30 mg/kg and 100 mg/kg CBZ in food also significantly reduced motor seizures, and blocked seizures in 33% and 89% of the rats, respectively. CBZ administered in food three times per day (100 mg/kg x3 CBZ in food) continuously blocked nearly all motor seizures over a 5-day period, and completely suppressed motor seizures in 50% of the animals tested. CONCLUSIONS: CBZ strongly suppresses spontaneous motor seizures, and single doses of CBZ in food are as effective as IP injections in rats with kainate-induced epilepsy. CBZ administered regularly in food continuously blocks nearly all motor seizures, and may provide a relatively simple method to test AEDs in chronic models of epilepsy.
Authors:
Heidi L Grabenstatter; Suzanne Clark; F Edward Dudek
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2007-08-17
Journal Detail:
Title:  Epilepsia     Volume:  48     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-19     Completed Date:  2008-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2287-95     Citation Subset:  IM    
Affiliation:
Department of Biomedical Sciences, Anatomy and Neurobiology Section, Colorado State University, Fort Collins, Colorado 80523, USA.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Anticonvulsants / administration & dosage*,  pharmacology*,  therapeutic use*
Carbamazepine / administration & dosage*,  pharmacology,  therapeutic use*
Cross-Over Studies
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Carriers / administration & dosage
Epilepsy / chemically induced*,  drug therapy,  prevention & control*
Food, Fortified*
Injections, Intraperitoneal
Kainic Acid*
Male
Pharmaceutical Preparations / administration & dosage*
Rats
Rats, Sprague-Dawley
Seizures / genetics,  prevention & control*
Grant Support
ID/Acronym/Agency:
NS048620/NS/NINDS NIH HHS; NS054414/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Drug Carriers; 0/Pharmaceutical Preparations; 298-46-4/Carbamazepine; 487-79-6/Kainic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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