| Anticonvulsant effect of intranigral fluoxetine. | |
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MedLine Citation:
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PMID: 1450936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bilateral focal injections of the serotonin uptake inhibitor, fluoxetine (1.75-7.0 nmol) into substantia nigra (SN) protected against convulsive seizures evoked by the focal injection of bicuculline methiodide into area tempestas, an epileptogenic site within the deep prepiriform cortex. Injection of fluoxetine unilaterally in SN or bilaterally into a site dorsal to SN was not anticonvulsant. Blockade of nigral gamma-aminobutyric acid (GABA) receptors with bicuculline in SN did not reverse the anticonvulsant action of intranigral fluoxetine. These data suggest that serotonergic transmission in SN exerts a seizure suppressing action which is independent of GABA transmission in SN. |
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Authors:
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A Pasini; A Tortorella; K Gale |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 593 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1993-01-06 Completed Date: 1993-01-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 287-90 Citation Subset: IM |
Affiliation:
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Georgetown University Medical Center, Washington, DC 20007. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticonvulsants / administration & dosage, pharmacology* Bicuculline / administration & dosage, analogs & derivatives Cerebral Cortex / drug effects* Convulsants / administration & dosage Fluoxetine / administration & dosage, pharmacology* Male Microinjections Rats Rats, Sprague-Dawley Seizures / chemically induced, physiopathology*, prevention & control Substantia Nigra / drug effects, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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NS20576/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Convulsants; 40709-69-1/bicuculline methiodide; 485-49-4/Bicuculline; 54910-89-3/Fluoxetine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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