Document Detail


Anticonvulsant activity in photosensitive baboons, Papio papio, of two new 1,5 benzodiazepines.
MedLine Citation:
PMID:  108705     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two new 1,5 benzodiazepines have been evaluated acutely as anticonvulsants in baboons, Papio papio, with photosensitive epilepsy. BAU 426 (8-Chlor-6-[2-chlorphenyl]-4H-s-triazolo-[4,3-a] [1,5-benzodiazepin-5-[6-H]on) and BAU 500 (analogue of BAU 426 with [2-trifluor methylphenyl] substituted for [2-chlorphenyl]), 0.1--5.0 mg/kg, were administered i.v. to baboons with and without priming with D,L allylglycine. BAU 426 or BAU 500, 0.1--0.2 mg/kg, produced partial or transient protection against photically induced myoclonus or epileptic responses. Complete protection, in the absence of signs of sedation or acute neurological toxicity, was seen 1--4 h after 0.5--2 mg/kg. EEG changes typical of benzodiazepines were seen for 1--3 h and clinical signs of sedation with some muscular hypotonia were evident for 1 h after either drug, 5 mg/kg. Clinical trials are required to determine if these compounds are superior to 1,4 benzodiazepines as anticonvulsants.
Authors:
B S Meldrum; R W Horton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychopharmacology     Volume:  60     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-07-25     Completed Date:  1979-07-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  277-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticonvulsants*
Benzodiazepines / pharmacology*
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Female
Haplorhini
Hypnotics and Sedatives / pharmacology
Muscle Tonus / drug effects
Papio*
Photic Stimulation
Photosensitivity Disorders / complications*
Seizures / etiology,  prevention & control
Time Factors
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Hypnotics and Sedatives; 12794-10-4/Benzodiazepines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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