| Anticonvulsant activity of the gamma-aminobutyric acid uptake inhibitor N-4,4-diphenyl-3-butenyl-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol . | |
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MedLine Citation:
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PMID: 8319739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The N-4,4-diphenyl-3-butenyl derivative of the glial selective gamma-aminobutyric acid (GABA) uptake inhibitor 4,5,6,7-tetrahydroisoxazolo [4,5-c]pyridin-3-ol (N-DPB-THPO), was tested for its ability to block sound-induced seizures in the audiogenic seizure-susceptible Frings mouse model of epilepsy. Following intracerebroventricular (i.c.v.) administration, N-DPB-THPO blocked tonic hindlimb extension in a dose- and time-dependent manner. At the doses tested no gross behavioral effects were noted. |
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Authors:
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H S White; J Hunt; H H Wolf; E A Swinyard; E Falch; P Krogsgaard-Larsen; A Schousboe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: European journal of pharmacology Volume: 236 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1993 May |
Date Detail:
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Created Date: 1993-07-30 Completed Date: 1993-07-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 147-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 84108. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Animals Anticonvulsants / administration & dosage, pharmacology* Dose-Response Relationship, Drug GABA Antagonists* Injections, Intraventricular Isoxazoles / pharmacology* Mice Seizures / prevention & control gamma-Aminobutyric Acid / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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N01-NS-9-2328/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/GABA Antagonists; 0/Isoxazoles; 132033-96-6/N-4,4-diphenyl-3-butenyl-4,5,6,7-tetrahydroisoxazolo(4,5-c)pyridin-3-ol; 56-12-2/gamma-Aminobutyric Acid |
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