Document Detail

Anticonvulsant activity of N,N'-bis[3-(3-substituted urea)propyl]piperazines.
MedLine Citation:
PMID:  1151634     Owner:  NLM     Status:  MEDLINE    
Several N,N'-bis[3-(3-substituted urea)propyl]piperazines were synthesized and characterized by their sharp melting points, elemental analyses, and IR spectra. All substituted piperazines were found to possess anticonvulsant activity, which was reflected by 20-70% protection observed against pentylenetetrazol-induced seizures in mice. Some of these compounds inhibited oxidation of pyruvic acid by rat brain homogenate. No correlation could be observed between the anticonvulsant activity possessed by these substituted piperazines and their ability to inhibit the oxidation of pyruvic acid.
A K Chaturvedi; J P Barthwal; S S Parmar; V I Stenberg
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  64     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1975 Mar 
Date Detail:
Created Date:  1975-11-06     Completed Date:  1975-11-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  454-6     Citation Subset:  IM    
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MeSH Terms
Anticonvulsants / pharmacology*,  toxicity
Brain / metabolism
Lethal Dose 50
Oxygen Consumption / drug effects
Piperazines / pharmacology*,  toxicity
Pyruvates / metabolism
Seizures / chemically induced
Urea / analogs & derivatives*,  pharmacology
Reg. No./Substance:
0/Anticonvulsants; 0/Piperazines; 0/Pyruvates; 54-95-5/Pentylenetetrazole; 57-13-6/Urea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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