Document Detail


Anticonvulsant activity of N,N'-bis[3-(3-substituted urea)propyl]piperazines.
MedLine Citation:
PMID:  1151634     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several N,N'-bis[3-(3-substituted urea)propyl]piperazines were synthesized and characterized by their sharp melting points, elemental analyses, and IR spectra. All substituted piperazines were found to possess anticonvulsant activity, which was reflected by 20-70% protection observed against pentylenetetrazol-induced seizures in mice. Some of these compounds inhibited oxidation of pyruvic acid by rat brain homogenate. No correlation could be observed between the anticonvulsant activity possessed by these substituted piperazines and their ability to inhibit the oxidation of pyruvic acid.
Authors:
A K Chaturvedi; J P Barthwal; S S Parmar; V I Stenberg
Related Documents :
8459404 - Orally active beta-lactam inhibitors of human leukocyte elastase. 2. effect of c-4 subs...
12946154 - N-acetyl-n'-methylamide derivative of (2s,3s)-1-amino-2,3-diphenylcyclopropanecarboxyli...
1255664 - Aminobenzioc acid diuretics. 8.(2) 3, 4-disubstituted 5-methylsulfonylbenzioc acids and...
9560184 - Chemical requirements for inhibition of gap junction communication by the biologically ...
688594 - Evaluation of continuous solvent extraction of organic acids from biological fluids.
19918794 - Intracellular redox imbalance and extracellular amino acid metabolic abnormality contri...
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  64     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1975 Mar 
Date Detail:
Created Date:  1975-11-06     Completed Date:  1975-11-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  454-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Anticonvulsants / pharmacology*,  toxicity
Brain / metabolism
Lethal Dose 50
Male
Oxygen Consumption / drug effects
Pentylenetetrazole
Piperazines / pharmacology*,  toxicity
Pyruvates / metabolism
Rats
Seizures / chemically induced
Urea / analogs & derivatives*,  pharmacology
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Piperazines; 0/Pyruvates; 54-95-5/Pentylenetetrazole; 57-13-6/Urea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of cyproterone acetate on uterine motility in rats.
Next Document:  Drug-biomolecule interactions: mechanisms and kinetics of interactions of biomolecules at interfaces...