Document Detail


The Anticonvulant Effect of Cooling in Comparison to α-Lipoic Acid: A Neurochemical Study.
MedLine Citation:
PMID:  23389664     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Brain cooling has pronounced effects on seizures and epileptic activity. The aim of the present study is to evaluate the anticonvulsant effect of brain cooling on the oxidative stress and changes in Na(+), K(+)-ATPase and acetylcholinesterase (AchE) activities during status epilepticus induced by pilocarpine in the hippocampus of adult male rat in comparison with α-lipoic acid. Rats were divided into four groups: control, rats treated with pilocarpine for induction of status epilepticus, rats treated for 3 consecutive days with α-lipoic acid before pilocarpine and rats subjected to whole body cooling for 30 min before pilocarpine. The present findings indicated that pilocarine-induced status epilepticus was accompanied by a state of oxidative stress as clear from the significant increase in lipid peroxidation (MDA) and superoxide dismutase (SOD) and significant decrease in reduced glutathione and nitric oxide (NO) levels and the activities of catalase, AchE and Na(+), K(+)-ATPase. Pretreatment with α-lipoic acid ameliorated the state of oxidative stress and restored AchE to nearly control activity. However, Na(+), K(+)-ATPase activity showed a significant decrease. Rats exposed to cooling for 30 min before the induction of status epilepticus revealed significant increases in MDA and NO levels and SOD activity. AchE returned to control value while the significant decrease in Na(+), K(+)-ATPase persisted. The present data suggest that cooling may have an anticonvulsant effect which may be mediated by the elevated NO level. However, brain cooling may have drastic unwanted insults such as oxidative stress and the decrease in Na(+), K(+)-ATPase activity.
Authors:
Yasser A Khadrawy; Heba S Aboulezz; Nawal A Ahmed; Haitham S Mohammed
Related Documents :
23484794 - Development of a small-animal focal brain irradiation model to study radiation injury a...
23895154 - Intravenous administration of tetramethylpyrazine reduces intestinal ischemia-reperfusi...
23306624 - Assessment of methyl methacrylate genotoxicity by the micronucleus test.
23095174 - Neuroprotective effects of alpinia katsumadai against experimental ischemic damage via ...
218644 - Action of dopamine on cyclic amp-tissue level in the rat pancreas. interaction with sec...
12548084 - Effects of long-term treatment with ketanserin on blood pressure variability and end-or...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-7
Journal Detail:
Title:  Neurochemical research     Volume:  -     ISSN:  1573-6903     ISO Abbreviation:  Neurochem. Res.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Medical Division, Medical Physiology Department, National Research Center, El-Bohouth St., P.O.: 12622, Giza, Egypt, yaserask@yahoo.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Spatiotemporal Expression of SKIP After Rat Sciatic Nerve Crush.
Next Document:  Patients' experience of health three years after structured physiotherapy or surgery for lumbar disc...