Document Detail


Anticoccidial efficacy of semduramicin in battery studies with laboratory isolates of coccidia.
MedLine Citation:
PMID:  1539028     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The anticoccidial activity of semduramicin against laboratory isolates of five species of poultry Eimeria was investigated. In laboratory scale battery trials, semduramicin at 20 to 30 ppm demonstrated broad-spectrum anticoccidial efficacy equivalent to salinomycin at 60 ppm. Also, semduramicin at 25 ppm was fed to uninfected cockerels in batteries for 21 days, and growth rate and feed efficiency were found to be equivalent to birds fed salinomycin at 60 ppm. Semduramicin was well tolerated when coadministered with tiamulin. Semduramicin demonstrated the same activity whether produced by semisynthesis or by direct fermentation.
Authors:
A P Ricketts; E A Glazer; T T Migaki; J A Olson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Poultry science     Volume:  71     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-04-02     Completed Date:  1992-04-02     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  98-103     Citation Subset:  IM    
Affiliation:
Central Research Division, Pfizer Inc., Groton, Connecticut 06340.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents / pharmacology,  therapeutic use
Chickens / parasitology*
Coccidiosis / drug therapy,  veterinary*
Diterpenes / pharmacology,  therapeutic use
Drug Therapy, Combination / pharmacology,  therapeutic use
Eimeria tenella / drug effects*
Ionophores / pharmacology,  therapeutic use
Male
Nigericin / analogs & derivatives*,  chemical synthesis,  pharmacology,  therapeutic use
Poultry Diseases / drug therapy*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Diterpenes; 0/Ionophores; 113378-31-7/semduramicin; 28380-24-7/Nigericin; 55297-95-5/tiamulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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