Document Detail

Anticoagulation therapy with heparin and warfarin in total knee arthroplasty for osteoarthritis knee.
MedLine Citation:
PMID:  19150995     Owner:  NLM     Status:  MEDLINE    
The authors evaluated the prophylactic protocols with unfractionated heparin (UFH) and warfarin in Japanese patients who underwent total knee arthroplasty (TKA) for osteoarthritis knee in regard to bleeding complications. Fifty-six patients who underwent TKA for osteoarthritis knee with the use of methylmethacrylate were included. Subcutaneous UFH and warfarin were administered for thromboprophylaxis to the first group of 26 patients. The second group of 30 patients did not receive any pharmacological thromboprophylaxis and were used as controls. No significant differences were found between the 2 groups for operative and postoperative blood loss. There were no cases with major bleeding as a complication, but for 2 cases, the international normalized ratio high value exceeded the remedy limits, and temporary dosage discontinuance was required. There were no clinically important bleeding events in the 2 groups. No heparin-induced thrombocytopenia or warfarin-induced skin necrosis occurred. The authors conclude that the protocol with UFH and warfarin is safe for thromboprophylaxis against deep venous thrombosis and pulmonary embolism after TKA in Japanese patients, but its efficacy can only be resolved with further studies.
Kazumasa Kimura; Shigeki Ohtani; Hiroshi Okamura; Nobukazu Ishii; Chieko Kishimoto; Kunihiko Konishi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis     Volume:  15     ISSN:  1076-0296     ISO Abbreviation:  Clin. Appl. Thromb. Hemost.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-19     Completed Date:  2009-03-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508125     Medline TA:  Clin Appl Thromb Hemost     Country:  United States    
Other Details:
Languages:  eng     Pagination:  109-12     Citation Subset:  IM    
Department of Orthopaedic Surgery, Kyohritsu General Hospital, Nagoya, Japan.
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MeSH Terms
Aged, 80 and over
Arthroplasty, Replacement, Knee* / adverse effects
Blood Loss, Surgical / statistics & numerical data
Heparin / therapeutic use*
Middle Aged
Osteoarthritis, Knee / surgery
Postoperative Complications / prevention & control
Prospective Studies
Pulmonary Embolism / prevention & control
Venous Thrombosis / prevention & control
Warfarin / therapeutic use*
Reg. No./Substance:
81-81-2/Warfarin; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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