Document Detail

Anticoagulation in prosthetic valve endocarditis.
MedLine Citation:
PMID:  6635725     Owner:  NLM     Status:  MEDLINE    
We reviewed the experience with infective endocarditis at some major US Army Medical Centers. One hundred patients were studied, comparing 82 patients who had native valve endocarditis (NVE) with 18 patients who had prosthetic valve endocarditis (PVE). Among patients with PVE, four had porcine valves and 14 had synthetic. None of the patients with NVE had received anticoagulants; 14 of 18 patients with PVE had received anticoagulants. The major causes of death were central nervous system hemorrhage, congestive heart failure, uncontrolled infection, and embolic phenomena. The principal cause of death in patients with PVE was CNS hemorrhage. Of the patients with PVE, 36% had symptomatic cerebral hemorrhage while receiving anticoagulants and 80% of them died.
J L Carpenter; C K McAllister
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  76     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1372-5     Citation Subset:  AIM; IM    
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Anticoagulants / adverse effects*
Aortic Valve / surgery
Cerebral Hemorrhage / chemically induced,  mortality
Drug Evaluation
Endocarditis, Bacterial / etiology*
Heart Failure / chemically induced
Heart Valve Prosthesis*
Mitral Valve / surgery
Postoperative Complications
Prothrombin Time
Retrospective Studies
Thromboembolism / chemically induced
Warfarin / adverse effects
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anticoagulants; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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