Document Detail


Anticoagulation in pregnancy with mechanical heart valves: 10-year experience.
MedLine Citation:
PMID:  18042775     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anticoagulation in pregnancy was evaluated in 33 women with a mechanical heart valve prosthesis who had 53 pregnancies between 1994 and 2006. Their mean age at valve operation was 24.4 +/- 5.4 years, and 22 (67%) had isolated mitral valve disease. Of these patients, 22 had a single pregnancy, 5 had 2 pregnancies, 3 had 3, and 3 had 4. In 43 pregnancies, the patients took warfarin throughout; in the other 10, heparin was used in the first trimester followed by warfarin until the last 15 days. Mean international normalized ratio and warfarin levels before, during, and after pregnancy were similar. Complications occurred in 3 (6%) women who had thrombosed valves: 2 (20%) in the heparin group and 1 (2%) who had warfarin only. Live births resulted from 37 (70%) pregnancies. There were significantly more abortions in the heparin group (6; 60%) than the warfarin group (8; 19%). Hemorrhage requiring transfusion occurred in 2 (5%) patients in the warfarin group. All live births resulted in healthy babies. It was concluded that anticoagulation with warfarin is safe during pregnancy in women with mechanical heart valves.
Authors:
Raja P Akhtar; Abdul R Abid; Hasnain Zafar; Masud A Cheema; Jawad S Khan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian cardiovascular & thoracic annals     Volume:  15     ISSN:  1816-5370     ISO Abbreviation:  Asian Cardiovasc Thorac Ann     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-28     Completed Date:  2008-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9503417     Medline TA:  Asian Cardiovasc Thorac Ann     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  497-501     Citation Subset:  IM    
Affiliation:
Department of Cardiac Surgery, Punjab Institute of Cardiology, Ghaus-ul-Azam Road, Lahore, Pakistan. rajapakhtar@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / chemically induced
Administration, Oral
Adult
Anticoagulants / administration & dosage,  adverse effects,  therapeutic use*
Drug Administration Schedule
Female
Heart Valve Prosthesis
Heart Valve Prosthesis Implantation / adverse effects*,  instrumentation
Hemorrhage / chemically induced
Heparin / administration & dosage,  adverse effects,  therapeutic use*
Humans
Pakistan
Patient Selection
Practice Guidelines as Topic
Pregnancy
Pregnancy Complications, Cardiovascular / prevention & control*
Prospective Studies
Prosthesis Design
Risk Assessment
Thrombosis / etiology,  prevention & control*
Time Factors
Treatment Outcome
Warfarin / administration & dosage,  adverse effects,  therapeutic use*
Chemical
Reg. No./Substance:
0/Anticoagulants; 81-81-2/Warfarin; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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