| Anticoagulation-associated Adverse Drug Events. | |
| | |
MedLine Citation:
|
PMID: 22114827 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
PURPOSE: Anticoagulant drugs are among the most common medications that cause adverse drug events (ADEs) in hospitalized patients. We performed a 5-year retrospective study at Brigham and Women's Hospital to determine clinical characteristics, types, root causes, and outcomes of anticoagulant-associated ADEs. METHODS: We reviewed all inpatient anticoagulant-associated ADEs, including adverse drug reactions (ADRs) and medication errors, reported at Brigham and Women's Hospital through the Safety Reporting System from May 2004 to May 2009. We also collected data about the cost associated with hospitalizations in which ADRs occurred. RESULTS: Of 463 anticoagulant-associated ADEs, 226 were medication errors (48.8%), 141 were ADRs (30.5%), and 96 (20.7%) involved both a medication error and ADR. Seventy percent of anticoagulant-associated ADEs were potentially preventable. Transcription errors (48%) were the most frequent root cause of anticoagulant-associated medication errors, while medication errors (40%) were a common root cause of anticoagulant-associated ADRs. Death within 30 days of anticoagulant-associated ADEs occurred in 11% of patients. After an anticoagulant-associated ADR, most hospitalization expenditures were attributable to nursing costs (mean $33,189 per ADR), followed by pharmacy costs (mean $7451 per ADR). CONCLUSION: Most anticoagulant-associated ADEs among inpatients result from medication errors and are, therefore, potentially preventable. We observed an elevated 30-day mortality rate among patients who suffered an anticoagulant-associated ADE and high hospitalization costs following ADRs. Further quality improvement efforts to reduce anticoagulant-associated medication errors are warranted to improve patient safety and decrease health care expenditures. |
| | |
Authors:
|
Gregory Piazza; Thanh Nha Nguyen; Deborah Cios; Matthew Labreche; Benjamin Hohlfelder; John Fanikos; Karen Fiumara; Samuel Z Goldhaber |
Related Documents
:
|
1481307 - Five cases of alcaligenes pseudobacteraemia. 17074867 - Effect of the introduction of a lumbar-puncture sticker and teaching manikin on junior ... 3321467 - Cornea donation: increasing tissue supplies. 7429147 - Is there a need for admission and discharge cognitive screening for the medically ill? 11799747 - Masseteric silent period in healthy young adults. 10792687 - An evaluation study of the didactic quality of clerkships. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of medicine Volume: 124 ISSN: 1555-7162 ISO Abbreviation: Am. J. Med. Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-11-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0267200 Medline TA: Am J Med Country: United States |
Other Details:
|
Languages: eng Pagination: 1136-42 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Care of the adult hodgkin lymphoma survivor.
Next Document: Venous thromboembolism prophylaxis for medical service-mostly cancer-patients at hospital discharge.