Document Detail

Anticoagulation after artificial valve replacement with or without atrial fibrillation: how much is really needed?
MedLine Citation:
PMID:  10695504     Owner:  NLM     Status:  MEDLINE    
Insertion of a mechanical artificial heart valve is an absolute indication for the use of lifelong oral anticoagulation, irrespective the presence or absence of atrial fibrillation. Depending on the type and position of the artificial valve the optimal International Normalized Ratio (INR) for these patients is between 2.5 and 4.5, although more prospective studies on the optimal range of oral anticoagulation are necessary. Addition of low dose antiplatelet therapy may further decrease the rate of thromboembolism, but also here more studies are needed. Patients with a bioprosthesis need only oral anticoagulation for the first three months following surgery in the absence of an indication for anticoagulation for other conditions. Atrial fibrillation is often seen in patients with artificial heart valves. Stroke prevention can be instituted by the mandatory oral anticoagulant therapy. The presence of atrial fibrillation and the use of oral anticoagulation prior to heart valve surgery support the indication for the insertion of a mechanical artificial heart valve. However, relative contraindications to oral anticoagulation and the presence of sinus rhythm may favor the use of a bioprosthesis.
F W Verheugt
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  82 Suppl 1     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  2000-03-22     Completed Date:  2000-03-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  130-5     Citation Subset:  IM    
Department of Cardiology, Heartcenter, University Hospital Nijmegen, The Netherlands.
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MeSH Terms
Anticoagulants / administration & dosage,  therapeutic use*
Atrial Fibrillation / etiology
Heart Valve Prosthesis
Heart Valve Prosthesis Implantation* / adverse effects
Heart Valves / surgery*
Thrombosis / etiology,  prevention & control*
Reg. No./Substance:

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