| Anticoagulation Control Quality Affects the D-Dimer Levels of Atrial Fibrillation Patients. | |
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MedLine Citation:
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PMID: 22185714 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Anticoagulation control quality affects the incidence of thromboembolic events in atrial fibrillation (AF) patients. However, the effects of anticoagulation control quality on the prothrombotic state of AF patients are unclear. Methods and Results: Ninety-five AF patients who had been treated with warfarin were prospectively followed-up for 449±92 days. We analyzed whether time in the therapeutic range (TTR) of the international normalized ratio (INR) of prothrombin time, percentage of INR values in the range (%INR), and coefficient of variation of INR values (CV-INR) were related to D-dimer levels. The mean values of TTR, %INR, and CV-INR were 62%, 59%, and 0.19, respectively, and their median values were 67%, 63%, and 0.19, respectively. TTR was significantly correlated with %INR (R(2)=0.917, P<0.01), but not with CV-INR (R(2)=0.050, P=0.26). The mean and median D-dimer levels were 0.79 and 0.60µg/ml, respectively. Low TTR, low %INR, and high CV-INR were found to contribute to high D-dimer levels (P=0.02, 0.03, and 0.02, respectively). Conclusions: In AF patients treated with warfarin, not only the duration outside the target INR range, but also the fluctuation in INR level may influence the prothrombotic state. |
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Authors:
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Yosuke Nakatani; Koichi Mizumaki; Kunihiro Nishida; Tadakazu Hirai; Masao Sakabe; Yoshitaka Oda; Shuji Joho; Akira Fujiki; Takashi Nozawa; Hiroshi Inoue |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-17 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: - ISSN: 1347-4820 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Second Department of Internal Medicine, Graduate School of Medicine, University of Toyama. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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