Document Detail

Anticoagulants in pregnancy.
MedLine Citation:
PMID:  8309994     Owner:  NLM     Status:  MEDLINE    
Pregnancy is associated with a prethrombotic state. Pulmonary embolism is the major cause of maternal mortality. Anticoagulant prophylaxis and therapy are therefore commonplace in pregnant women. Those with inherited and acquired thrombophilic conditions are at increased risk and special considerations arise in management. Heparin has recently become the favoured anticoagulant drug in pregnancy. Its use carries risks of osteopaenia and thrombocytopaenia, as well as haemorrhage, in the mother. Warfarin is teratogenic and may also cause haemorrhagic complications in mother and fetus. Few clinical trial data exists for guidance on optimal anticoagulant regimes during pregnancy and the puerperium and details of management will depend upon the personal preferences of patient and clinician, after due consideration of the perceived risks and benefits in the individual clinical situation.
M Greaves
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pharmacology & therapeutics     Volume:  59     ISSN:  0163-7258     ISO Abbreviation:  Pharmacol. Ther.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1994-03-16     Completed Date:  1994-03-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905840     Medline TA:  Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  311-27     Citation Subset:  IM    
Department of Haematology, Royal Hallamshire Hospital, Sheffield, U.K.
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MeSH Terms
Abnormalities, Drug-Induced / etiology
Anticoagulants / adverse effects,  therapeutic use*
Heparin / adverse effects
Postpartum Period
Pregnancy Complications, Cardiovascular / drug therapy*
Thromboembolism / drug therapy*,  prevention & control
Warfarin / adverse effects
Reg. No./Substance:
0/Anticoagulants; 81-81-2/Warfarin; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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