Document Detail

Anticoagulant therapy for venous thromboembolism during pregnancy: a systematic review and a meta-analysis of the literature.
MedLine Citation:
PMID:  23205953     Owner:  NLM     Status:  Publisher    
Venous thromboembolism (VTE) is one of the most relevant causes of maternal death in industrialized countries. Low molecular weight heparin (LMWH), continued throughout the entire pregnancy and puerperium, is currently the preferred treatment for patients with acute VTE occurred during pregnancy. However, evidences on the efficacy and safety of anticoagulant drugs in this setting are extremely limited. We carried out a systematic review and a meta-analysis of the literature to provide an estimate of the risk of bleeding complications and VTE recurrence in patients with acute VTE during pregnancy treated with antithrombotic therapy. Weight mean incidence (WMI) of bleeding and thromboembolic events and the corresponding 95% confidence interval (CI) were calculated. Eighteen studies for a total of 981 pregnant patients with acute VTE were included. LMWH was prescribed to 822 patients, the remaining were treated with unfractionated heparin. Anticoagulant therapy was associated with a WMI of major bleeding of 1.41 % (95% CI:0.60-2.41;I) antenatally and of 1.90% (95% CI:0.80-3.60%;) during the first 24 hours after delivery. The estimated WMI of recurrent VTE during pregnancy was 1.97% (95% CI:0.88-3.49% I(2) : 39.5%). Anticoagulant therapy appears to be safe and effective for the treatment of pregnancy related VTE, but the optimal dosing regimens remain uncertain. © 2012 International Society on Thrombosis and Haemostasis.
E Romualdi; F Dentali; E Rancan; A Squizzato; L Steidl; S Middeldorp; W Ageno
Related Documents :
9707383 - Maternal smoking during pregnancy and psychiatric adjustment in late adolescence.
15709053 - Vitamin c prevents the effects of prenatal nicotine on pulmonary function in newborn mo...
12331823 - Lippes loop in the broad ligament (report of a case of extraperitoneal migration of the...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-3
Journal Detail:
Title:  Journal of thrombosis and haemostasis : JTH     Volume:  -     ISSN:  1538-7836     ISO Abbreviation:  J. Thromb. Haemost.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101170508     Medline TA:  J Thromb Haemost     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 International Society on Thrombosis and Haemostasis.
Research Center on Thromboembolic Disorders and on Antithrombotic Therapies Department of Clinical Medicine, University of Insubria, Varese, Italy Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A Prospective Population-Based Cohort Study Of The Prevalence, Incidence And Impact Of Obsessive-Com...
Next Document:  The tomato SlSHINE3 transcription factor regulates fruit cuticle formation and epidermal patterning.