Document Detail

Anticoagulant therapy in cerebrovascular disease: review and meta-analysis.
MedLine Citation:
PMID:  3041650     Owner:  NLM     Status:  MEDLINE    
Sixteen acceptably randomized studies of anticoagulant therapy after cerebral or retinal ischemia or infarction are reviewed and the results among 1,046 anticoagulated patients and 1,071 controls are analyzed. The following conclusions are derived. 1) Anticoagulant therapy has not been shown to be better than control management after transient ischemia or nonprogressing ischemic stroke; this is true whether the control management was deliberately ineffectual treatment (generally studies completed in 1974 or earlier) or platelet antiaggregant therapy (pooled results of three recent studies). 2) Although a study done 30 years ago demonstrated no benefit, a recent study showed benefit from anticoagulant therapy in patients who had had cerebral emboli of cardiac origin; additional controlled data are needed. 3) There is evidence that patients with thrombosis in evolution might benefit from anticoagulant therapy; additional controlled data are needed.
S Jonas
Publication Detail:
Type:  Clinical Trial; Journal Article; Review    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  19     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-09-08     Completed Date:  1988-09-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1043-8     Citation Subset:  IM    
Department of Neurology, New York University School of Medicine, New York 10016.
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MeSH Terms
Anticoagulants / therapeutic use*
Cerebrovascular Disorders / drug therapy*
Clinical Trials as Topic
Random Allocation
Reg. No./Substance:
Erratum In:
Stroke 1989 Apr;20(4):562

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