Document Detail


Anticoagulant therapy: basic principles, classic approaches and recent developments.
MedLine Citation:
PMID:  22732252     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The standard multipotent anticoagulants (unfractionated and low molecular weight heparins, antagonists of vitamin K) are commonly used for treatment and/or prophylaxis of different thrombotic complications, such as deep vein thrombosis, thrombophilia, pulmonary embolism, myocardial infarction, stroke and so on. Advantages and shortcomings of these anticoagulants are considered. The modern tendencies to use small selective direct inhibitors of thrombin or factor Xa are surveyed. The search of the new targets in the coagulation cascade for development of new promising anticoagulants and improvement in antithrombotic therapy is discussed.
Authors:
Elena I Sinauridze; Mikhail A Panteleev; Fazoil I Ataullakhanov
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-21
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  -     ISSN:  1473-5733     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
aNational Research Center for Hematology, Ministry of Health and Social Development bCenter for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences cPhysical Department, Moscow State University dHemaCore LLC eFederal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia.
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