| Anticoagulant therapy: basic principles, classic approaches and recent developments. | |
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MedLine Citation:
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PMID: 22732252 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The standard multipotent anticoagulants (unfractionated and low molecular weight heparins, antagonists of vitamin K) are commonly used for treatment and/or prophylaxis of different thrombotic complications, such as deep vein thrombosis, thrombophilia, pulmonary embolism, myocardial infarction, stroke and so on. Advantages and shortcomings of these anticoagulants are considered. The modern tendencies to use small selective direct inhibitors of thrombin or factor Xa are surveyed. The search of the new targets in the coagulation cascade for development of new promising anticoagulants and improvement in antithrombotic therapy is discussed. |
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Authors:
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Elena I Sinauridze; Mikhail A Panteleev; Fazoil I Ataullakhanov |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-21 |
Journal Detail:
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Title: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis Volume: - ISSN: 1473-5733 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102551 Medline TA: Blood Coagul Fibrinolysis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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aNational Research Center for Hematology, Ministry of Health and Social Development bCenter for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences cPhysical Department, Moscow State University dHemaCore LLC eFederal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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