Document Detail

Anticlastogenic activity exhibited by botryosphaeran, a new exopolysaccharide produced by Botryosphaeria rhodina MAMB-05.
MedLine Citation:
PMID:  18022685     Owner:  NLM     Status:  MEDLINE    
Biopolymers such as exopolysaccharides (EPS) are produced by microbial species and possess unusual properties known to modify biological responses, among them are antimutagenicity and immunomodulation. Botryosphaeran, a newly described fungal (1-->3; 1-->6)-beta-d-glucan produced by Botryosphaeria rhodina MAMB-05, was administered by gavage to mice at three doses (7.5, 15 and 30mg/kgb.w.per day) over 15 days, and found to be non-genotoxic by the micronucleus test in peripheral blood and bone marrow. Botryosphaeran administered at doses of 15 and 30mg EPS/kgb.w. decreased significantly (p<0.001) the clastogenic effect of cyclophosphamide-induced micronucleus formation resulting in a reduction of the frequency of micronucleated cells of 78 and 82% in polychromatic erythrocytes of bone marrow, and reticulocytes in peripheral blood, respectively. The protective effect was dose-dependent, and strong anticlastogenic activity was exerted at low EPS doses. Variance analysis (ANOVA) showed no significant differences (p<0.05) among the median body weights of the groups of mice treated with botryosphaeran during experiments evaluating genotoxic and protective activities of botryosphaeran. This is the first report on the biological activity attributed to botryosphaeran.
Carolina C B O Miranda; Robert F H Dekker; Juliana M Serpeloni; Eveline A I Fonseca; Ilce M S Cólus; Aneli M Barbosa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-18
Journal Detail:
Title:  International journal of biological macromolecules     Volume:  42     ISSN:  0141-8130     ISO Abbreviation:  Int. J. Biol. Macromol.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-01     Completed Date:  2008-04-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909578     Medline TA:  Int J Biol Macromol     Country:  England    
Other Details:
Languages:  eng     Pagination:  172-7     Citation Subset:  IM    
Dept de Bioquímica e Biotecnologia - CCE, Universidade Estadual de Londrina, C.P. 6001, C.E.P. 86051-990, Londrina-PR, Brazil.
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MeSH Terms
Ascomycota / chemistry*
Glucans / chemistry*,  pharmacology*,  secretion
Mutation / genetics
Reticulocytes / drug effects
Reg. No./Substance:
0/Glucans; 0/Mutagens; 0/botryosphaeran

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