| Anticlastogenic activity exhibited by botryosphaeran, a new exopolysaccharide produced by Botryosphaeria rhodina MAMB-05. | |
| | |
MedLine Citation:
|
PMID: 18022685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Biopolymers such as exopolysaccharides (EPS) are produced by microbial species and possess unusual properties known to modify biological responses, among them are antimutagenicity and immunomodulation. Botryosphaeran, a newly described fungal (1-->3; 1-->6)-beta-d-glucan produced by Botryosphaeria rhodina MAMB-05, was administered by gavage to mice at three doses (7.5, 15 and 30mg/kgb.w.per day) over 15 days, and found to be non-genotoxic by the micronucleus test in peripheral blood and bone marrow. Botryosphaeran administered at doses of 15 and 30mg EPS/kgb.w. decreased significantly (p<0.001) the clastogenic effect of cyclophosphamide-induced micronucleus formation resulting in a reduction of the frequency of micronucleated cells of 78 and 82% in polychromatic erythrocytes of bone marrow, and reticulocytes in peripheral blood, respectively. The protective effect was dose-dependent, and strong anticlastogenic activity was exerted at low EPS doses. Variance analysis (ANOVA) showed no significant differences (p<0.05) among the median body weights of the groups of mice treated with botryosphaeran during experiments evaluating genotoxic and protective activities of botryosphaeran. This is the first report on the biological activity attributed to botryosphaeran. |
| | |
Authors:
|
Carolina C B O Miranda; Robert F H Dekker; Juliana M Serpeloni; Eveline A I Fonseca; Ilce M S Cólus; Aneli M Barbosa |
Related Documents
:
|
7870085 - Sister-chromatid exchanges after exposure to metal-containing emissions. 12202625 - Induction of chromosomal aberrations by dacarbazine in somatic and germinal cells of mice. 23135605 - Dose-related effects of salvinorin a in humans: dissociative, hallucinogenic, and memor... 1789255 - Biochemical and pharmacological properties of ci-972, a novel 9-deazaguanine analog pur... 3744135 - Pharmacokinetics of intravenously and subcutaneously administered fragmin in healthy vo... 23053255 - Effect of aprepitant on the pharmacokinetics of the cyclin-dependent kinase inhibitor d... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-10-18 |
Journal Detail:
|
Title: International journal of biological macromolecules Volume: 42 ISSN: 0141-8130 ISO Abbreviation: Int. J. Biol. Macromol. Publication Date: 2008 Mar |
Date Detail:
|
Created Date: 2008-02-01 Completed Date: 2008-04-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7909578 Medline TA: Int J Biol Macromol Country: England |
Other Details:
|
Languages: eng Pagination: 172-7 Citation Subset: IM |
Affiliation:
|
Dept de Bioquímica e Biotecnologia - CCE, Universidade Estadual de Londrina, C.P. 6001, C.E.P. 86051-990, Londrina-PR, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Ascomycota / chemistry* Female Glucans / chemistry*, pharmacology*, secretion Male Mice Mutagens* Mutation / genetics Reticulocytes / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Glucans; 0/Mutagens; 0/botryosphaeran |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Adolescent Coping Process Interview: measuring temporal and affective components of adolescent r...
Next Document: Preparation and characterization of calcium pectinate gel beads entrapping catechin-loaded liposomes...