| Anticholinergic and sedative medicines - Prescribing considerations for people with dementia. | |
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MedLine Citation:
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PMID: 22276284 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background Older people with dementia may be particularly susceptible to cognitive impairment associated with anticholinergic and sedative medicines. This impairment may be misattributed to the disease process itself. Objective This review examines clinical considerations associated with using anticholinergic and sedative medicines in people with dementia or incipient cognitive impairment. It highlights issues associated with concomitant use of cholinesterase inhibitors and anticholinergic medicines, and pharmacotherapy of conditions that commonly occur in people with dementia. Discussion Use of medicines with anticholinergic or sedative properties may result in adverse events by increasing the overall anticholinergic or sedative load. Patients may benefit from clinicians reviewing the anticholinergic load of the current medicine regimen before the initiation of cholinesterase inhibitors or memantine. Reducing the number and dose of anticholinergic and sedative medicines may improve cognitive function and reduce the likelihood of adverse events. |
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Authors:
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J Simon Bell; Carmel Mezrani; Natalie Blacker; Tammy Leblanc; Oliver Frank; Christopher P Alderman; Simone Rossi; Debra Rowett; Russell Shute |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Australian family physician Volume: 41 ISSN: 0300-8495 ISO Abbreviation: Aust Fam Physician Publication Date: 2012 Jan-Feb |
Date Detail:
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Created Date: 2012-01-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0326701 Medline TA: Aust Fam Physician Country: Australia |
Other Details:
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Languages: eng Pagination: 45-9 Citation Subset: IM |
Affiliation:
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BPharm(Hons), PhD, MPS, is Associate Professor, Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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