Document Detail

Anticholinergic poisoning in colicky infants treated with hyoscyamine sulfate.
MedLine Citation:
PMID:  9270398     Owner:  NLM     Status:  MEDLINE    
Hyoscyamine, one of the principal alkaloid components of belladonna, is a potent anticholinergic agent. Because of its anticholinergic properties, hyoscyamine sulfate drops are often prescribed for the treatment of colic in infants. Anticholinergic poisoning in infants is rare. However, five cases are reported of infants with anticholinergic toxicity following the administration of hyoscyamine drops for the treatment of colic. Common presenting symptoms included irritability, tachycardia, and erythematous flushed skin. These cases emphasize the need for a heightened awareness by emergency physicians and pediatricians of possible anticholinergic toxicity caused by the use of hyoscyamine for infant colic.
J H Myers; D Moro-Sutherland; J E Shook
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of emergency medicine     Volume:  15     ISSN:  0735-6757     ISO Abbreviation:  Am J Emerg Med     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-09-10     Completed Date:  1997-09-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8309942     Medline TA:  Am J Emerg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  532-5     Citation Subset:  IM    
Pediatric Emergency Medicine, Texas Children's Hospital, Baylor College of Medicine, Houston, USA.
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MeSH Terms
Atropine / poisoning*,  therapeutic use
Colic / drug therapy*
Infant, Newborn
Muscarinic Antagonists / poisoning*,  therapeutic use
Poisoning / therapy
Reg. No./Substance:
0/Muscarinic Antagonists; 51-55-8/Atropine

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