| Anticariogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans. | |
| | |
MedLine Citation:
|
PMID: 16492529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The occurrence of dental caries is mainly associated with oral pathogens, especially cariogenic Streptococcus mutans. Preliminary antibacterial screening revealed that the extract of Myristica fragrans, widely cultivated for the spice and flavor of foods, possessed strong inhibitory activity against S. mutans. The anticariogenic compound was successfully isolated from the methanol extract of M. fragrans by repeated silica gel chromatography, and its structure was identified as macelignan by instrumental analysis using 1D-NMR, 2D-NMR and EI-MS. The minimum inhibitory concentration (MIC) of macelignan against S. mutans was 3.9 microg/ml, which was much lower than those of other natural anticariogenic agents such as 15.6 microg/ml of sanguinarine, 250 microg/ml of eucalyptol, 500 microg/ml of menthol and thymol, and 1000 microg/ml of methyl salicylate. Macelignan also possessed preferential activity against other oral microorganisms such as Streptococcus sobrinus, Streptococcus salivarius, Streptococcus sanguis, Lactobacillus acidophilus and Lactobacillus casei in the MIC range of 2-31.3 microg/ml. In particular, the bactericidal test showed that macelignan, at a concentration of 20 microg/ml, completely inactivated S. mutans in 1 min. The specific activity and fast-effectiveness of macelignan against oral bacteria strongly suggest that it could be employed as a natural antibacterial agent in functional foods or oral care products. |
| | |
Authors:
|
J Y Chung; J H Choo; M H Lee; J K Hwang |
Related Documents
:
|
20181349 - Novel aspects of quantitation of immunogenic wheat gluten peptides by liquid chromatogr... 9373519 - Enforcement of food packaging legislation. 18758149 - Physicochemical interactions of metformin hydrochloride and glibenclamide with several ... 18712879 - Effects of nitrogen fertilization on the phenolic composition and antioxidant propertie... 18569709 - Antiacetylcholinesterase and antioxidant ent-kaurene diterpenoid, melissoidesin from is... 19008259 - Development and validation of an improved test for the measurement of human faecal elas... 116299 - Food and water intake in the non-deprived pigeon after chlordiazepoxide administration. 22470019 - Ground roasted peanuts leads to a lower post-prandial glycemic response than raw peanuts. 17311959 - Low plasma vitamin b-12 in kenyan school children is highly prevalent and improved by s... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2005-06-28 |
Journal Detail:
|
Title: Phytomedicine : international journal of phytotherapy and phytopharmacology Volume: 13 ISSN: 0944-7113 ISO Abbreviation: Phytomedicine Publication Date: 2006 Mar |
Date Detail:
|
Created Date: 2006-02-22 Completed Date: 2006-05-09 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9438794 Medline TA: Phytomedicine Country: Germany |
Other Details:
|
Languages: eng Pagination: 261-6 Citation Subset: IM |
Affiliation:
|
Department of Biomaterials Science and Engineering, Yonsei University, Seoul, South Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anti-Bacterial Agents
/
isolation & purification,
pharmacology,
therapeutic use Bacteria / drug effects Cariostatic Agents / isolation & purification, pharmacology, therapeutic use Dental Caries / prevention & control* Lignans / isolation & purification, pharmacology*, therapeutic use Magnetic Resonance Spectroscopy / methods Microbial Sensitivity Tests Myristica fragrans / chemistry* Oils, Volatile / pharmacology, therapeutic use Phytotherapy* Plant Extracts / pharmacology*, therapeutic use Seeds / chemistry Streptococcus mutans / drug effects* Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Bacterial Agents; 0/Cariostatic Agents; 0/Lignans; 0/Oils, Volatile; 0/Plant Extracts; 0/macelignan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tyrosinase inhibitory lignans from the methanol extract of the roots of Vitex negundo Linn. and thei...
Next Document: Abietanes from Plectranthus grandidentatus and P. hereroensis against methicillin- and vancomycin-re...