Document Detail


Anticardiolipin and antinuclear antibodies in cancer patients--a case control study.
MedLine Citation:
PMID:  10812496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate patients with cancer for the frequency of IgG and IgM aCL and ANA in comparison to a group of age- and sex-matched controls. METHODS: Serum levels of IgG and IgM anticardiolipin antibodies (aCL), antinuclear antibodies (ANA) and anticytoplasmic antibodies were evaluated in 145 cancer patients, including 20 patients with thromboembolic disease (TED) and compared with age- and sex-matched controls. RESULTS: Higher levels of IgG aCL were found in patients compared to controls (p < 0.02). However, there appeared to be no difference in serum aCL levels between TED and the remaining cancer patients. No difference was found in the frequency of antinuclear and anticytoplasmic antibodies between patients and controls and the autoantibody presence in patients was usually not associated with concomitant autoimmune disease. CONCLUSION: Apart from increased levels of non-thrombogenic associated IgG aCL, there was no evidence for significantly enhanced B cell autoreactivity in this large collection of cancer patients compared to controls.
Authors:
J B Armas; J Dantas; D Mendonça; R Farto; M Ribeiro; G Herrero-Beaumont; J Gouveia; N J McHugh
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  18     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2000 Mar-Apr
Date Detail:
Created Date:  2000-07-03     Completed Date:  2000-07-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  227-32     Citation Subset:  IM    
Affiliation:
Hospital de Santo Espirito de Angra do Heroísmo, Azores, Portugal. jacome@mail.telepac.pt
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Animals
Antibodies, Anticardiolipin / blood*
Antibodies, Antineutrophil Cytoplasmic / blood
Antibodies, Antinuclear / blood*
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Female
Fluorescent Antibody Technique, Indirect
Humans
Immunoglobulin G / blood
Immunoglobulin M / blood
Male
Mice
Middle Aged
Neoplasms / blood*
Thrombophlebitis / blood
Chemical
Reg. No./Substance:
0/Antibodies, Anticardiolipin; 0/Antibodies, Antineutrophil Cytoplasmic; 0/Antibodies, Antinuclear; 0/Immunoglobulin G; 0/Immunoglobulin M

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