Document Detail

Anticardiolipin antibodies are no marker for survived myocardial infarction.
MedLine Citation:
PMID:  2376955     Owner:  NLM     Status:  MEDLINE    
Antiphospholipid antibodies--both the lupus anticoagulant and anticardiolipin antibodies--are closely associated with arterial and venous thrombosis. In this prospective trial the IgM- and IgG-anticardiolipin antibodies in serum were determined in acute and chronic coronary artery disease. Seventy-four unselected males (34-87 years, mean 60) were included in the study. All patients underwent coronary angiography; infectious and autoimmune diseases were exclusion criteria. Sixteen patients had coronary artery disease (group A), 34 showed coronary stenoses with prior infarction (B), and 14 had survived an acute myocardial infarction (C), whereas 10 patients revealed no significant coronary narrowing (D; controls). The major risk factors were the same for all groups. Neither the IgM- nor the IgG-anticardiolipin antibody levels showed any significant difference in the four groups. The severity of coronary artery disease did not correlate to these antibodies. Furthermore, no correlation was found between elevated anticardiolipin antibodies and thrombocyte levels. Thus, a higher anticardiolipin level does not appear to be a marker for recurrent cardiovascular events.
B Eber; E Kronberger-Schaffer; H Brussee; G Klima; A Obernosterer; M Toporsch; J Dusleag; W Klein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Klinische Wochenschrift     Volume:  68     ISSN:  0023-2173     ISO Abbreviation:  Klin. Wochenschr.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-09-05     Completed Date:  1990-09-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985205R     Medline TA:  Klin Wochenschr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  594-6     Citation Subset:  IM    
Medizinische Universitätsklinik Graz, Kardiologie, Osterreich.
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MeSH Terms
Aged, 80 and over
Autoantibodies / analysis*
Cardiolipins / immunology*
Coronary Disease / diagnosis*,  immunology
Follow-Up Studies
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Middle Aged
Myocardial Infarction / diagnosis*,  immunology,  mortality
Prospective Studies
Reg. No./Substance:
0/Autoantibodies; 0/Cardiolipins; 0/Immunoglobulin G; 0/Immunoglobulin M

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